图1. NGFR蛋白结构。Ngfr基因敲除小鼠 在2011年的一项研究中，研究人员通过在4~6号外显子之间插入loxP-Neo-loxP元件导致Ngfr（p75NTR）基因被破坏（图2），从而丧失基因功能。图2. p75NTR基因敲除小鼠打靶策略[7]。该基因的纯合敲除小鼠在初期生长速度缓慢，在提尾悬空时，表现出后肢紧握反应的神经性表型。除此之...
7. Bogenmann E, Thomas PS, Li Q, Kim J, Yang LT, Pierchala B, Kaartinen V. Generation of mice with a conditionalfor the p75(NTR) neurotrophin receptor gene. Genesis. 2011 Nov;49(11):862-9. doi: 10.1002/dvg.20747. Epub 2011 Aug 22. PMID: 21413144; PMCID: PMC3543998....
基因简称(symbol) NGFR [HGNC] [GeneCards] [NCBI] 基因种类(locus group) protein-coding gene 同源简称(alias symbol) TNFRSF16|CD271|p75NTR 基因家族代码(gene_family_id) 471|782 [HGNC] [GenScript] omim代码 162010 entrez码 4804 [Vega] ensembl基因码 ENSG00000064300 [Ensembl] 基因家族...
NGFR (Nerve Growth Factor Receptor, also known as CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR), located on 17q21.33, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 45183 Da protein composed of 427 amino acids. ...
Parsi S, Soltani BM, Hosseini E, Tousi SE, Mowla SJ. Experimental verification of a predicted intronic microRNA in human NGFR gene with a potential pro-apoptotic function. PLoS One 2012; 7: e35561.Parsi S et al (2012) Experimental verification of a predicted intronic microRNA in human ...
官方名 NGFR 官方全称 nerve growth factor receptor HGNC ID HGNC:7809 别称 CD271, low affinity nerve growth factor receptor, p75NTR, TNFR superfamily, member 16, TNFRSF16 位点类型 gene with protein product 染色体位置 17q21.33 基因家族 CD moleculesTumor necrosis factor receptor superfamily ...
Entrez Gene ID: (Pig) 100525607, (Sheep) 101119064, (Dog) 491071, (Human) 4804, (Rabbit) 100349095 功能 beta-amyloid binding signal transducer activity receptor activity transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity neurotrophin TRKA receptor binding protein...
106:12771. 3. Kidd SK, et al. 2008. Brain Res.1195:113. 4. Peters EM, et al. 2007. Am J Pathol. 171:1872. 5. Jansen P, et al. 2007. Nat Neurosci. 10:1449. Gene ID 4804 View all products for this Gene ID UniProt View information about CD271 on UniProt.org Documentatio...
Entrez Gene:4804 Swiss Prot:P07174 Source:KLH conjugated synthetic peptide derived from human NGFR:301-400/427 Purification:affinity purified by Protein A Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeat...
Gene ID (NCBI) 4804 Alternative Names CD271;Gp80-LNGFR;p75(NTR);p75NTR;TNFRSF16 Application Notes: The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user. WB 1:500 - 1:2000 Western blot analysis of extracts of various...