Settanni G ;Cattaneo A ;Carloni P.Molecular dynamics simulations of the NGF-TrkA domain 5 complex and comparison with biological data.Biophys J.2003.2282-2292Settanni G ,Cattaneo A ,Carloni P. Molecular dynamics simulations of the NGF-TrkA domain 5 complex and comparison with biological data[J...
and the third loop connecting strands B and C form one end of the dumbbell, now shown by the crystal structure of the NGF-TrkA domain 5 complex to be pointing away from the membrane. The other, membrane-facing end contains three hairpin loops as well as four short b strands arranged in...
有相关研究证明NGF主要和TrkA以及p75神经生长因子受体(p75 nerve growth factor receptor,p75NGFR)两种因子相结合产生不同的生物效应。单独看一种神经因子,p75NGFR与NGF结合主要调节细胞凋亡;而TrkA则主要调节神经细胞的修复功能。将两种因子相互作用考虑在内,当TrkA与p75NGFR均高浓度表达时,p75NGFR调节TrkA的活性。 NGF...
(3). NGF was initially isolated from the mouse submandibular gland as a 7S complex composed of three non-covalently linked subunits, alpha, beta, and gamma. It is now known that both the alpha and gamma subunits of NGF are members of the kallikrein family of serine proteases while the ...
(3). NGF was initially isolated from the mouse submandibular gland as a 7S complex composed of three non-covalently linked subunits, alpha, beta, and gamma. It is now known that both the alpha and gamma subunits of NGF are members of the kallikrein family of serine proteases while the ...
As in the total TrkA immunoprecipitates, we found CHC and AP2 in a complex with activated TrkA and showed that the amount increased markedly following NGF treatment. The association with CHC peaked at 2 min and returned to baseline levels by 15 min. These findings are consistent with the ...
(or -10) to the death-inducing complex DISC.5,6,14 In both type I and type 2 tumour cells, TRAIL- induced apoptosis is regulated by the equilibrium between functional (DR4 and DR5) and decoy (DcR1, DcR2 and OPG) TRAIL receptors, the level of caspase-3, caspase-8, caspase-9 and...
dependent on the repression of p75(NTR); and that the well-known potentiation by p75(NTR) of the TrkA signaling does not concern all the effects induced by NGF but primarily the PI3K cascade and its associated mTORC2, a complex known to play an important role in neural cell differentiation...
p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in ...
· NGF-TrkA axis Background Dry eye disease (DED) is one of the most frequent ophthalmologic disorders, affecting up to 50% of the population, and is considered a complex, multifactorial * Balázs Sonkodi bsonkodi@gmail.com 1 Department of Health Sciences and Sport Medicine, Hungarian ...