growth and differentiation of nerve cells. It is distributed throughout the body and plays different pathophysiological roles according to the combined receptors. TrkA is its high affinity receptor, and many studies have shown ...
Producing cells release NGF that bind and activate TrkA high affinity receptors to mediate NGF-driven signaling. NGF also binds to low affinity p75 (NTR) receptors, which belong to the death receptor family (2). Although NGF has been classically described as favoring neuron survival and ...
Glucose fluctuation promotes neuronal apoptosis, which plays a central role in diabetic encephalopathy (DE). Nerve growth factor (NGF), and its interaction with high-affinity (TrkA) and low-affinity (p75NTR) receptors, are involved in neuronal survival. NGF/TrkA contributes to the activation of ...
(1996). "Postnatal changes in the expression of the trkA high-affinity NGF recepotr in primary sensory neurons." Eur. J neurosci. 8: 2204-2208.Ennett DLH, Averill S, Clary DO, Priestley JV, McMahon SB. 1996. Postnatal changes in the expression of the trkA high-affinity NGF receptor in...
NGF also binds to low affinity p75 (NTR) receptors, which belong to the death receptor family (2). Although NGF has been classically described as favoring neuron survival and differentiation, NGF can promote apoptosis in cells that contain p75 (NTR) and lack TrkA. NGF can induce neuron death...
This study aimed to test the hypothesis that the NGF-tropomyosin receptor kinase A (TrkA) (high-affinity NGF receptor) pathway plays a role in the calcification process of human articular chondrocytes (hACs). A 14-aa small peptide of NGF (Nsp) previously shown to activate NGF signaling in ...
P75NTR(NerveGrowthFactorlowaffinitYreceptorP75)在结肠神经系 统中的分布及与结肠神经系统发育的关系。方法采用一抗为PGP9.5 (proteingeneproduct9.5)、NGF、TrkA、P75NTR的免疫组化技术,显 示结肠神经系统不同发育阶段肠壁中的神经元。结果人胚胎发育有明显的 ...
affinity (9). TrkA is often referred to as the high-affinity receptor. However, most high affinity binding is mediated by the interaction of NGF receptor with TrKA. Both NGF and its receptors are expressed during development, adult life and aging in many cell types in CNS and PNS, immune ...
NGF binds to both a high affinity tyrosine kinase receptor trkA and a low affinity receptor p75. Nociceptors are primary afferent neurons that respond to potentially tissue damaging stimuli. NGF can sensitize these neurons so that they show an increased response to thermal and chemical stimuli. ...
第1套尼氏染色;第2套乙酰胆碱酯酶(acetylcholinesterase,AChE)组织化学染色;从第3、4套中挑选部分有移植区的切片作胆碱乙酰转移酶(choline acetyltransferase,ChAT)和低亲和力神经生长因子受体(low affinity nerve growth factor receptor,LNGFR)免疫组织化学染色,一抗为购自宝灵曼公司的小鼠ChAT和LNGFR单克隆抗体,工作浓度...