在一项新的研究中,来自苏黎世大学和卡罗林斯卡大学医院的研究人员对小鼠为实验对象,旨在更好地了解中枢神经系统中的一类胶质细胞——NG2胶质细胞(NG2 glia cell),在朊病毒诱导的神经变性中的作用。在这种称为朊病毒病(prion disease)的神经退行性疾病中,在这种疾病中,一种叫做朊病毒的蛋白的异常堆积诱发神经毒性。相...
少突胶质细胞谱系细胞,包括少突胶质细胞前体细胞(NG2胶质细胞)在各种神经退行性疾病中发生明显的变化。 基于此,2024年5月27日苏黎世大学神经病理学研究所Adriano Aguzzi研究团队在Nature neuroscience杂志发表了“NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling”...
越来越多的证据表明,细胞自主和非细胞自主机制都有助于神经退行性过程。少突胶质细胞谱系细胞,包括少突胶质细胞前体细胞(NG2胶质细胞)在各种神经退行性疾病中发生明显的变化。 基于此,2024年5月27日苏黎世大学神经病理学研究所Adriano Aguzzi研究团队在Nature neuroscience杂志发表了“NG2 glia protect against prion neuro...
原文以NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis为标题发布在BMC Medicine期刊 中科院脑科学与智能技术卓越创新中心（神经科学研究所）神经科学国家重点实验室周嘉伟研究团队于2019月11日在BMC Medicine 期刊在线发表了题为NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis的...
Loss of NG2 glia enhanced the biosynthesis of prostaglandin E2 (PGE2) by microglia, which augmented prion neurotoxicity through binding to the EP4 receptor. Pharmacological or genetic inhibition of PGE2 biosynthesis attenuated prion-induced neurodegeneration in COCS and mice, reduced the enhanced ...
Emerging evidence suggests that NG2-glia not only act as the precursors of oligodendrocytes but also possess many other biological properties and functions. For example, NG2-glia can form synapse with neurons and participate in energy metabolism and immune regulation. Under pathological conditions, NG...
NG2 glia, also known as oligodendrocyte precursor cells (OPCs), play an important role in proliferation and give rise to myelinating oligodendrocytes during early brain development. In contrast to other glial cell types, the most intriguing aspect of NG2 glia is their ability to directly sense ...
中科院脑科学与智能技术卓越创新中心(神经科学研究所)神经科学国家重点实验室周嘉伟研究团队于2019月11日在BMC Medicine 期刊在线发表了题为NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis的研究论文。该研究深入探讨了神经免疫学的一个关键科学问题,即大脑的固有免疫是如何调控的。阅读链接: ...
Cycling glial precursors—“NG2-glia”—are abundant in the developing and mature central nervous system (CNS). During development, they generate oligodendrocytes. In culture, they can revert to a multipotent state, suggesting that they might have latent stem cell potential that could be harnessed ...
2021年9月30日,上海交通大学医学院童小萍研究团队在Nature Communications杂志上在线发表了题为NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety的最新研究成果。在此项工作中,作者率先揭示了NG2胶质细胞突触调控的新机制。