神经丝轻链(NfL)是神经退行性疾病的一种有前途的生物标志物,在神经轴突损伤时可在脑脊液和血液中测量。虽然传统上使用CSF分析,但现在基于血液的检测提供了一种侵入性较小的替代方法。NfL水平与阿尔茨海默病病、肌萎缩侧索硬化、多发性硬化和亨廷顿舞蹈病等...
ALS-NFL作为预测性生物标志物 受nusinersen治疗的脊髓性肌肉萎缩症(SMA)儿童的脑脊液(CSF)神经丝轻链(NFL)水平正常化并与运动改善相关,在病程最早接受治疗的儿童中发现了最大的益处。 神经退行性变的另外两个生物标记物(脑脊液tau和胶质纤维酸...
神经丝轻链(NfL)是神经退行性疾病的一种有前途的生物标志物,在神经轴突损伤时可在脑脊液和血液中测量。虽然传统上使用CSF分析,但现在基于血液的检测提供了一种侵入性较小的替代方法。NfL水平与阿尔茨海默病病、肌萎缩侧索硬化、多发性硬化和亨廷顿舞蹈病等疾病的严重程度和进展相关。临床试验证明了其作为MS和als中药...
CSF and blood NfL have been shown to be increased in patients with multiple sclerosis (MS), Alzheimer’s Disease (AD), Parkinson’s disease (PD), stroke, traumatic brain injury (TBI), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD) and other neurological disorders. The Simoa...
We test this in the setting of HIV brain injury in which cerebrospinal fluid (CSF) NFL has been well characterized and noted to be a reliable biomarker of neuronal injury. Blood and CSF NFL were highly correlated and measurement of plasma NFL was able to detect both severe and subclinical ...
Results: We found strong correlations between blood and CSF concentrations of NfL (ρ≥ 0.73–0.84, p ≤ 0.001). Blood NfL was increased in patients with MSA, PSP, and CBS (i.e., all APD groups) when compared to patients with PD as well as healthy controls in all cohorts ( p < ...
Results: We found strong correlations between blood and CSF concentrations of NfL (ρ≥ 0.73–0.84, p ≤ 0.001). Blood NfL was increased in patients with MSA, PSP, and CBS (i.e., all APD groups) when compared to patients with PD as well as healthy controls in all cohorts ( p <...
There was no difference in NfL levels in CSF and plasma in OVT73 sheep compared to age-matched WT sheep. Conclusions: These results show that synaptic... G Sapp 被引量: 0发表: 0年 CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis....
A fraction of these proteins diffuses into the blood, where concentrations are typically 50 to 100-fold lower than in CSF (4). Nf-L elevations have been demonstrated with traumatic brain injury, multiple sclerosis, frontotemporal dementia, Alzheimer’s disease, and other neurodegenerative diseases ...
在AD患者中,三种生物标志物:淀粉样蛋白Aβ、P-Tau和NfL,在血液与CSF的数值异常同步,因此可以成为临床实践和试验中早期诊断、预后或监测疾病进展和治疗效果的有力工具【1】。《阿尔茨海默病源性轻度认知障碍诊疗中国专家共识2021》指出,在认知功能减退等临床症状出...