Authors - Bingchuan Geng View Article human WB Oncogene Monoacylglycerol lipase blockades the senescence-associated secretory phenotype by interfering with NF-κB activation and promotes docetaxel efficacy in prostate cancer Authors - Jianpeng Yu View ArticleProteintech...
Cellular senescence is a state of irreversible cell-cycle arrest, thought to contribute to neurodegenerative diseases partially via induction of a chronic pro-inflammatory phenotype. In this study, we used a mouse model of genetically enhanced NF-魏B activity (nf魏b1-/- ), characterized by low-...
In human epidermal neoplasia, oncogenic RAS-induced senescence is reversed by the inhibition of NF-KB by IKB-α, suggesting that NF-KB is required for the oncogene-induced senescence response [74]. Therefore, inhibiting NF-KB can actually exacerbate tumor progression in certain contexts. In ...
Melanoma cells can enter the process of senescence, but whether they express a secretory phenotype, as reported for other cells, is undetermined. This is o... M Ohanna,S Giuliano,C Bonet,... - 《Genes Dev》 被引量: 193发表: 2011年 Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhan...
NF-kappaB hyper- activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog 2011; 7: e1002025. 35 Wang PH, Gu ZH, Wan DH, Zhang MY, Weng SP, Yu XQ et al. Litopenaeus vannamei Toll-interacting protein (LvTollip) is ...
REFERENCES Ahmad I, Patel R, Singh LB, Nixon C, Seywright M, Barnetson RJ, Brunton VG, Muller WJ, Edwards J, Sansom OJ, Leung HY (2011) HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer. Proc Natl Acad Sci USA 108(39): 16392–16397 Andela VB, Gordon...
MSC senescence after tissue injury significantly impairs the regeneration of injured tissue and results in a false commitment to cell differentiation, causing an osteogenic-lipogenic imbalance [40]. Senescent TDSCs can impair tissue homeostasis by reprogramming tissue healing and releasing factors associated...
ERBB2-PTGS2 axis promotes intervertebral disc degeneration by regulating senescence of nucleus pulposus cells 2023, BMC Musculoskeletal Disorders Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration 2023, Cell Proliferation View all citing articles on ScopusView...
A prospective epigenetic paradigm between cellular senescence and epithelial-mesenchymal transition in organismal development and aging. Epigenetic states can govern the plasticity of a genome to be adaptive to environments where many stress stimuli and insults compromise the homeostatic sys... S Kishi,PE...
senescence-acceleratedmouse(SAMP8)andpartlyexplorethe mechanismofEAonAlzheimer’sdisease(AD)fromneuralcell adhesion. MethodsSAMP8wastakenasanimalmodelofAD.Thetreatment ofacupuncturonBaihui(Du20)andYongquan(Kid1)withEAwas appliedoncedailyandlastedfor21days.Aftertreatment,the ...