目的:探讨冠心病合并糖尿病患者的影响因素以及分析血糖,血脂,LCN2,IL-1β,NF-kB与心踝血管指数的相关性.方法:选取本院就诊的118例冠心病患者作为研究对象.根据是否合并有2型糖尿病,分为冠心病组(n=61)和冠心病合并糖尿病组(n=57).并选取同时期在本院体检的健康人群50例作为对照组.比较各组间基本资料,血清L...
散宾昵称还不能重复创建的收藏夹默认收藏夹内容:【生物外刊文献阅读 | 肝癌LIFR LCN2 铁死亡】(下)证实肝癌抑制基因LIFR通过NF-kB途径负调控Lcn2,LCN2熬合铁离子抗铁死亡,如果您对当前收藏夹内容感兴趣点击“收藏”可转入个人收藏夹方便浏览
组1的基因与细胞分裂细胞功能有关,组2的基因与细胞凋亡细胞功能有关,组3基因与抗氧化应激保护作用细胞功能有关。23.在本发明方法的一个优选实施方案中,所述方法包括:确定选自由bcl2、bcl2l1、ccnd2、skp2、csf1、nox1和serpine2组成的组1中的三个或更多个基因例如3、4、5、6或7个基因的表达水平;及确定选...
The influence of LCN2 on colorectal cancer (CRC) cell chemoresistance and ferroptosis were evaluated by in vitro and in vivo approaches. The interaction between LCN2, NF-& kgreen;B and ferroportin (FPN) was assessed by western blots, immunohistochemistry and dual luciferase reporter assays. ...
This cumulates in NF-kB pathway activation with increased production of CHF, LCN2 and C3, which cause neurodegeneration. The neurotoxic effect was investigated by exposing hiPSC-derived neurons to astrocyte-conditioned media, which severely reduced neurite outgrowth capacities. Rescue experiments targeting...
by the endogenous Rosa26 promoter.Surprisingly, compared to wild-type mice, adult male Liv-Ikk2ca mice had higher hepatic mRNA expression of Ikk2 and classical NF-kB targets (e.g. Lcn2 and A20), as well as IKK1, NIK, and RelB, but no changes in markers of inflammation or fibrosis....
LCN2的含量,肺组织病理切片及IKK2,p-IKBα,NF-KB,MUC5AC蛋白表达量.结果:各个剂量的桔梗汤总皂苷均可显著改善COPD模型大鼠的肺功能受损,降低COPD大鼠肺灌洗液中IL-6,IL-8,IL-1β的含量,降低血清中S100A8,S100A9,LCN1,LCN2的含量,且均呈现良好的量效关系;另外高剂量的桔梗汤总皂苷在上述所有指标的检测中...