与旨在抑制NF-κB活性的传统癌症治疗相比,这项研究开发了一种称为HOPE的新方法,该方法专注于激活癌细胞内的外源效应基因CRISPR-Cas13a,通过利用先前构建的NF-κB特异性启动子DMP来实现,然后靶向并抑制癌基因的表达TERT, PLK1, KRAS和真菌学在mRNA水平。我们评价了HOPE在各种培养细胞中的抗肿瘤作用,证实它能明显诱导...
促炎症性细胞因子如TNF、IL-1、IL-6水平升高与胰腺导管腺癌(PDAC)的不良预后密切相关。研究发现,KRASG12D可通过活化AP1诱导IL-1α表达,导致肿瘤细胞中的NF-κB激活。反过来,NF-κB激活也可启动IL-1α-SQSTM1表达,形成IL-1α-SQSTM1正反馈环路,从而诱导和维持NF-κB...
HMGCL的下调与较大的肿瘤大小和较短的总生存时间有关。在一项功能性研究中,HMGCL的过度表达增加了β-羟基丁酸盐(β-HB)的含量,并抑制了肺癌细胞的致瘤性,而HMGCL缺失促进了KP(KrasG12D;P53f/f)小鼠的从头开始肿瘤发生。 从机制上讲,肿瘤坏死因子α(TNFα)治疗降低了HMGCL蛋白水平,并且IKKβ与HMGCL相互作用并...
KRAS NF-kB is involved in the development of zinc resistance and reduced curability in prostate cancerHolubovaM.AxmanovaGumulecJ.RaudenskaSztalmachovaBabulaP.AdamingentaconnectMetallomics
Kras is a common driver mutation of PDAC, contributing to progression and chemotherapy resistance. Additionally, inflammation is implicated in the development of PDAC and NF魏B is recognized as a key mediator of inflammation and has been frequently observed to be upregulated in PDAC. Ref-1/APE1...
(2009).systematicrnainterferencerevealsthatoncogenickras-drivencancersrequiretbk1.nature462:108-112.4.blakely,c.m.,pazarentzos,e.,olivas,v.,asthana,s.,yan,j.j.,tan,i.,hrustanovic,g.,chan,e.,lin,l.,neel,d.s.,newton,w.,bobb,k.l.,fouts,t.r.,meshulam,j.,gubens,m.a.,jablons,d.m...
近日,中山大学生命科学学院崔隽教授课题组在Advanced Science上发表了题为“TRIM14 Promotes Non-canonical NF-kB Activation by Modulating p100/p52 stability via Selective Autophagy”的研究论文。论文阐明了E3泛素连接酶TRIM14通过选择性自噬调控转录因子p100/p52的稳定性,正向干预非经典NF-kB信号通路的分子机制,同时...
NRAS抗体, HRAS抗体, KRAS抗体, Rabbit Anti-NRAS Polyclonal Antibody价格:￥1500/支产品详情:概述 别名 NRAS抗体, HRAS抗体, KRAS抗体;GTPase N... 包装规格:50ul,100ul 用途:- 用途:- 货号:abs121086 品牌:爱必信(absin) 产地:上海 anti相关产品报价更多> ...
KRAS G13D BaF3 面议 GLP2R/CRE-Luc/HEK293 面议 GLP2R/β-Arrestin/CHO 面议 GLP1R&GIPR Dual Reporter Cell 面议 产品简介 TLR9/NFkB-Luc/HEK293,冻存条件:90% FBS+10% DMSO;培养基:MEM+10%FBS+1% non-essential amino acids(NEAA)+1 mM Na pyruvate+50 μg/ml Hygromycin B+2ug/ml pu...
Activating mutations of the prototypical oncogene KRAS drive proliferation in all pancreatic ductal adenocarcimomas, but have never been found in pancreatic endocrine tumors, which more commonly inactivate tumor suppressors such as MEN1,... M Parker,K Mohankumar,C Punchihewa,... 被引量: 273发表...