TLR2-MyD88-NF-kappa B pathwayTNF-alphaIL-6Proteinuria is an important risk factor for chronic kidney diseases (CKD). Several studies have suggested that proteinuria initiates tubulointerstitial inflammation, while the mechanisms have not been fully understood. In this study, we hypothesized whether ...
TLRs activate the TIRAP/MyD88 dependent pathway. This recruitment of adapters triggers a signaling cascade and ultimately the activation of JNKs and ERK. Those kinases activate transcription factors such as NF-<kappa>B, eventually leading to the synthesis of many inflammatory cytokines. Several ...
MyD88 is considered as one of the most crucial adaptors in TLR signaling pathway. MyD88 may be influential to interferon regulatory factors (IRFs), while t... XXT Xuan - Developmental and Comparative Immunology: Ontogeny, Phylogeny, Aging: The Official Journal of the International Society of De...
Atractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-κB signaling in vitro TLR4/MD-2 complex-mediated MyD88-dependent activation of NF-κB and Akt promotes tumor-associated immunosuppression in epithelial ovarian cancer (EOC) via ....
In the present study, we aimed to investigate the protective effects of DEX and examine whether its mechanism was associated with the TLR4/MyD88/NF-kappa B signaling pathway.Yang, JingWu, YoupingXu, YanJia, JiXi, WenbinDeng, HuiTu, Weifeng...
Furthermore, we show that the intracellular Toll/IL-1 receptor (TIR) domain of Nv-TLR can interact with the human TLR adapter proteins MAL and MYD88. We demonstrate that the coral pathogen Vibrio coralliilyticus causes a rapidly lethal disease in N. vectensis and that heat-inactivated V. ...
Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent. Cattle and humans are susceptible to infection with the Gram-negative intracellular bacterium Brucella abortus. Heat-killed B. abortus (HK...
Purpose: To evaluate the effect of the TLR2 (Toll-like receptor 2)/MyD88/NF-B axis on the allograft rejection after penetrating keratoplasty (PK). Methods: The PK rat models were randomly divided into four groups: allograft group, dexamethasone group, PDTC group and isograft group. The ...
TLR4/MyD88/NF-kappa B signaling pathwayCoronary microembolization (CME) is a common complication during the treatment of acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI). Nicorandil can be used to prevent myocardial injury after PCI to reduce the incidence of coronary no-...
Currently, a picture is emerging which suggests that ABC-DLBCL critically depends on sustained activity of the NFκB pathway, which, among others, is achieved through numerous distinct genetic aberrations, including CD79A/B-, CARD11-, and MYD88 mutations. Further genomic aberrations include ...