Finally, a recent manuscript describes the role of NF-Y in wound-induced tissue regeneration in Hofstenia miamia, specifically leading to production of neurons and, ultimately, of a “new” brain [150]. NF-Y was suspected because of the prominence of its CCAAT matrix in time-course experimen...
Last monthNFreturned with the stirring new single“HOPE”(NF Real Music/Virgin Music). The song finds the multi-Platinum hitmaker at his most raw and unfiltered as he assesses his musical journey thus far and looks to the future. Hope is accompanied by a suitably uplifting visual, which cap...
Although little is known about its cellular function, recent studies have revealed that PHF20 is a component of H4K16 histone acetyltransferase 'male absent on the first' (MOF) complex, which can bind to methylated Lys residue on the histone tail21,22. Moreover, PHF20-deficient mice ...
Recent articles have shown that macrophages are associated with allograft rejection [3]. More specifically, macrophages have been detected in acute antibody-mediated and cell-mediated rejection [4, 5], and have also been implicated in both mouse and human chronic allograft injury models [6, 7]....
[103,106,107]. Until now, a high number of autophagy regulators have been introduced and from a molecular standpoint, AMPK, Beclin-1, PI3K/Akt/mTOR, ATGs, and non-coding RNA are the most prominent regulators of autophagy. Based on recent advances, autophagy regulates various hallmarks of ...
Yang Y, Wang H, Kouadir M, Song H, Shi F. Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death Dis. 2019;10:128. Article PubMed PubMed Central Google Scholar Grzelczyk J, Szwajgier D, Baranowska-Wójcik E, Budryn G, Zakłos-Szyda ...
Our most recent studies demonstrate that RhoGDIα SUMOylation at lys-138 is crucial for its inhibition of colon cancer cell migration and invasion [15]. In the current study, we showed that RhoGDIα is p65 downstream mediator responsible for its promotion of BC migration. F-box and WD ...
The role of the transcription factor NF- B, particularly its coupling to inflammation and cancer, has generated considerable interest in recent years. NF- B in the skin is crucial for morphogenesis and homeostasis. Perturbations in its activity are linked to developmental skin defects, inflammatory ...
Recent studies have shown that exposure to a lipopolysaccharide (LPS)-preconditioned culture environment can promote the functional properties and trophic effects of MSCs in defending inflammatory conditions [14, 16,17,18]. However, it remains uncertain whether exosomes from LPS-preconditioned MSCs (LPS...
(NF-κB) in inflammatory response approach is a key signal transduction pathway.NF-κB has been well known as a regulator participating in inflammation and immunity reaction.Recent studies have shown that not only sumoylation of NF-κB inhibited protein(IκBa) involves in the regulation of NF-...