NF-Kappa B pathwayDNA methylation, an essential epigenetic alteration, is tightly linked to a variety of biological processes, such as immune response. To identify the epigenetic regulatory mechanism in Pacific oyster ( Crassostrea gigas ), whole-genome bisulfite sequencing (WGBS) was conducted on C...
predominantly in stromal cells. Inhibition of the expression and activity of PRMT5 blunted endometrial decidualization in mice. Inhibition of PRMT5 activity impaired human endometrial stromal cell decidualization partly by activating the NF-kappa B (NF-κB) signaling pathway, while overexpression...
between RA patients and healthy controls identified using GEO datasets GSE93272 and GSE89408, respectively; B, intersections of the top 1,000 DEGs from both datasets; C, KEGG pathway enrichment analysis of the intersecting genes; D, LY96 as a gene enriched in the NF-kappa B signaling pathway...
S3e). We further found that TNF-α-NF-κB signaling pathway was significantly enriched in TFC-1 cells compared to the TFC-2 subtype according to the results of GO_KEGG signaling pathway analysis and gene set enrichment analysis (GSEA) (Fig. 2i, j and Fig. S3f). This indicates the ...
According to the transcriptome analysis and enrichment KEGG pathway in our study, we have showed that IS﹊nduced osteogenic differentiation and calcification of human aortic smooth muscle cells via PI3K/Akt/NF│蔅 signaling pathway.doi:10.1002/jemt.23369Xin He...
同时,预测 YKS 血中活性成分的 972 个潜在靶点,经交集分析得到 98 个共同靶点,构建蛋白 - 蛋白相互作用(PPI)网络,发现 AKT1、TNF、IL1B 等为核心靶点。GO 和 KEGG 富集分析显示,这些靶点主要富集于 PI3K-Akt、NF-κB、TNF 等信号通路,提示 YKS 可能通过调控这些通路发挥作用。
NF-kappa B signaling pathway, TNF-signaling pathway and p53 signaling pathway, which are involved in aging and inflammation (Fig.6C). Specifically, the peaks identified candidate genomic loci at NFκB genes, including NFκB1 (gene ID: 18033, location: chr3: 135397308–135397660) and Rela (gen...
CAFs upregulate C3 via the NF-Kappa B pathway.AA heat map highlights differentially expressed inflammatory cytokine genes between CAF2 and CAF1 (n = 3).BKEGG pathway enrichment analysis identifies pathways significantly associated with genes differentially expressed in CAF2 compared to CAF1.CImmuno...
KEGG analysis revealed significant changes in the NF-кB signaling pathway following L-selectin inhibition (Fig. S3). Subsequently, western blot was used to examine both the total and phosphorylated protein levels associated with the NF-κB signaling pathways. Compared to the LPS treatment group, ...
The nuclear factor kappa B (NF-κΒ) pathway, as a critical proinflammatory pathway, contributes to M1 polarization[19]. Suppression of the NF-κΒ pathway has been demonstrated to deactivate the priming signal of the pyrin domain-containing 3 (NLRP3) inflammasome, leading to attenuation of the...