NF-κB（Nuclear Factor kappa-light-chain-enhancer of activated B cells）通路是一种在细胞信号传递中极为重要的途径，它在 调控免疫反应、炎症反应、细胞生长与死亡等多种生理过程中起着关键作用。这一通路能够响应多种刺激，包括促炎细胞因子、自由基、紫外线辐射、细菌和病毒感染等，
快速了解NF-κB 通路 NF-κB(Nuclear Factor kappa-light-chain-enhancer of activated B cells)通路是一种在细胞信号传递中极为重要的途径,它在 调控免疫反应、炎症反应、细胞生长与死亡 等多种生理过程中起… 陶术 NF-κB:又一个枢纽与焦点 小鬼星云发表于蛋白质和分... NF-κB通路抑制剂 爱必信生物发表于...
4. Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. Published 2013 Aug 2. 5. Beinke S, et al. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J. 2004;382(P...
of NF-κB Subunits by Phosphorylation. Cells. 2016;5(1):12. Published 2016 Mar 18.4. Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. Published 2013 Aug 2.5. Beinke S, et al. Functions of NF-kappaB1 and NF-kappaB2 in ...
4. Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. Published 2013 Aug 2. 5. Beinke S, et al. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J. 2004;382(Pt 2):393-409. ...
kappa-B, NF-κB) 和其他导致促炎分子合成的转录因子,从而引发一种促炎免疫反 应 [2].动物模型实验性自身免疫性脑脊髓炎具备多发性硬化的组织病理 学和免疫学方面的特征,是研究多发性硬化的理想动物模型 [3].在多发 性硬化和实验性自身免疫性脑脊髓炎的发病过程中,TLRs/MyD88/NF-κB 信号通路通过调节树突状...
当细胞受到脂多糖刺激时,经过一系列信号转导,进一步激活NF-κB抑制物的激酶(inhibitor of nuclear factor kappa-B kinase,IKKs),活化IKK复合体(包括IKKα及IKKβ),使得NF-κB复合物中的抑制成分IκB磷酸化而脱颗粒,迅速与NF-κB分离,促使NF-κB活化,后迁移至核内,诱导多种炎性细胞因子表达[23]。这些结果提示,...
4. Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86. Published 2013 Aug 2. 5. Beinke S, et al. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J. 2004;382(Pt 2):393-409. 6. Giridharan S, Sriniv...
(MAPK) and nuclear factor kappa B (NF-κB) signaling pathways, which increased the phosphorylation of Erk1/2, JNK, p38 and NF-κB p65, promoting secretion of cytokines tumor necrosis factor α (TNF-α), interleu...
Nuclear factor kappa B (NF-κB) transcription factors regulate several important physiological processes, including inflammation and immune responses, cell growth, apoptosis, and the expression of certain viral genes. Therefore, the NF-κB signaling pathway has also provided a focus for pharmacological ...