2. ___( compare) with that old computer, the new one is smaller but works faster. 3. Jack, ___brother works in our company, is going to give us a talk on how to learn English. 4. One of the ___( require) for a fire is that the material be heated to its burning tempera...
As illustrated in the scheme (Fig.1c), six-week-old male ApoE − / − mice were randomly and investigator-blindly divided into 5 groups (G1-G5: normal, control, VHPK-PLGA, colchicine, VHPK-PLGA@COL; 5 mice/group). Mice in G1, the normal group, were fed a normal c...
The story is obviously a showcase for VERA-ELLEN and on that level it's a bit of a disappointment. She's pert, pretty and knows how to dance. But poor David NIVEN, as the millionaire, has to wait a good half-hour before he even makes an appearance. He ambles through his role ...
also regulates the expression and localization of NF-κB during OA41. It seems that regulation of NF-κB pathway is a key mechanism in controlling articular cartilage homeostasis. Our findings that Hippo pathway or YAP modulates NF-κB signaling activity provide additional insights on how the NF-...
As seen in other tissues, NF-κB activation in kidney cells is negatively regulated by different factors. Nephrin, an Ig superfamily member located at the slit diaphragm of glomerular podocytes, serves as a negative regulator of NF-κB signaling in podocytes [87]. Although precisely how nephrin ...
The main reason that DEN is not a complete carcinogen in mice that are more than 4 weeks old is the nearly complete absence of proliferating hepatocytes [38]. Guobin He and Michael Karin npg 161 Thus, any agent that induces hepatocyte proliferation should function as a tumor promoter. Indeed...
The 8 weeks old, male C57BL/6 mice (18−22 g, Animal Experiment Center of Wuhan University, Hubei, China) were maintained in standard cages at controlled conditions of temperature (22 ± 2 °C) with relative humidity of 50 ± 10 %, 12 h light/dark cycle and free ac...
Collectively, these data strongly support the conclusion that POP2 is unique to primates and very likely unique to Old World and hominid primates. As Old World primates are thought to have diverged from New World primates approximately 40 mya, and hominids from Old World primates approximately 25...
Thus, additional research is needed to establish whether and how proteins identified in this analysis as putative SOCS2 targets are indeed ubiquitinated by SOCS2 and how they contribute to its cellular functions, including inflammation. Nonetheless, as it stands, this is the first report of a ...
Although the differential downregulation of Grp78/94 could be a potential determinant of different neuropathologies in CNS neurons, how loss of Grp78/94 mediates motor neuronal pathologies such as abnormal nuclear morphology remains unclear. In addition, it is still uncertain how NF-Y inactivation in...