总之,本研究确定了一种分子机制,表明TOC1的磷酸化如何改变其相位、稳定性以及与共同调节因子的物理相互作用,从而精确地相位PHG表达以控制光周期下胚轴生长。 论文ID原名:TOC1clock protein phosphorylation controls complex formation w...
Rashid, D., Newell, K., Shama, L. & Bradley, R. A requirement for NF-protocadherin and TAF1/Set in cell adhesion and neural tube formation.Dev. Biol.291, 170–181 (2006). ArticleCASGoogle Scholar Piper, M., Dwivedy, A., Leung, L., Bradley, R.S. & Holt, C.E. NF-protocadh...
Fig. 4: CHD3NEMO suppresses vFLIP-mediated NF-κB transcriptional activity and disrupts NEMO-vFLIP complex formation. a CHD3NEMO, but not control peptide CHD2NEMO or CHD4NEMO, inhibits NF-κB transcriptional activity significantly in BC-3 NF-κB-luc PEL cells in a dose-dependent manner at ...
The skin healing rate was calculated on the 1st,3rd,5th and 7th day of administration ,and the scab formation,decrustation and healing were recorded. The contents of IL- 1β,IL-6,IL-10,TNF-α,hydroxyproline(HYP),collagen Ⅰ(Col Ⅰ)and Col Ⅲ in skin tissue were detected by ELISA. ...
以下是应用时空云平台STOmics Cloud的StereoCopilot模块生成的文章概要,并辅以人工审核,供了解参考。 1、髓系细胞与甲状腺细胞亚群相互作用通过NF-κB促进其迁移和滤泡形成 Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB Nature Communications; ...
PMMA particle stimulation of mature osteoclast formation from RANKL-primed osteoclast precursor cells was blocked by all three inhibitors. To further test the efficacy of NF-kB blockade, experiments were performed with the TAT:IkB46-317 mutant peptide in whole bone marrow cultures that contain ...
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation Nat. Genet., 39 (2007), pp. 99-105, 10.1038/ng1937 View in ScopusGoogle Scholar Coppe et al., 2008 J.P. Coppe, C.K. Patil, F. Rodier, Y. Sun, D.P. Mu...
We show that, as in the crystal, RelB forms an intertwined homodimer in solution. We suggest that the transiently stable RelB homodimer might prevent its rapid degradation, allowing for heterodimer formation with p50 and p52. 展开 关键词: Animals Mice Crystallography, X-Ray Protein Structure, ...
Monomethylated at Lys-310 by SETD6. Monomethylation at Lys-310 is recognized by the ANK repeats of EHMT1 and promotes the formation of repressed chromatin at target genes, leading to down-regulation of NF-kappa-B transcription factor activity. Phosphorylation at Ser-311 disrupts the interaction...
Histo- logical and electron microscopic analyses of the optic nerve showed unimpaired oligodendrocyte densities (wild type, WT: 877.2±27.7 cells/mm2, RelACNSKO: 851.9±48.4 cells/mm2; P ¼ 0.43) and normal myelin sheath formation in RelACNSKO mice as assessed by g-ratios (WT: 0.71±0.02, ...