The factors secreted from breast cancer cells, including IL-1, IL-6, prostaglandin E2 (PGE2) and TNFα, play a crucial role in breast cancer-mediated osteoclast activation.48,49 These secreted factors stimulate osteoblasts to produce RANKL.2,36 IL-1 and IL-6 stimulate RANKL expression via ...
Liu et al. BMC Cancer (2021) 21:1184 https://doi.org/10.1186/s12885-021-08185-w RESEARCH ARTICLE Open Access MKL1 regulates hepatocellular carcinoma cell proliferation, migration and apoptosis via the COMPASS complex and NF-κB signaling Zhao Liu1, Jiuzheng Sun1, Chuanzhi Li1, Liyou Xu1...
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Macrophages play important roles in the initiation and modulation of host defense mechanisms through the production of proinflammatory mediators (e.g., nitric oxide, cytokines, and prostaglandin E2 (PGE2) [5]. Various signal transduction pathways are involved in the inflammatory process and contribute ...
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