Next-generation sequencing (NGS) technology has a striking impact on genomics research, especially in complex diseases, including cancer. NGS technology is allowing the discovery of novel genomic alterations and screening for known driver mutations and structural alterations as well as understanding ...
The application of next-generation sequencing (NGS) in cancer research has been instrumental in identifying genes related to cancer, improving our insight into tumor diversity, and uncovering mutations that lead to tumorigenesis. In a recentBench Tip webinar, three presenters discussed their...
Next generation sequencing in cancer research and clinical application The wide application of next-generation sequencing (NGS), mainly through whole genome, exome and transcriptome sequencing, provides a high-resolution and g... D Shyr,L Qi - 《Biological Procedures Online》 被引量: 106发表: ...
Since the sequencing of the first whole cancer genome was completed in 2008, next-generation sequencing (NGS) technologies have introduced a new paradigm into cancer genetics. Numerous studies have now employed whole-genome sequencing (WGS) and whole-exome sequencing (WES) to determine the somatic...
The wide application of next-generation sequencing (NGS), mainly through whole genome, exome and transcriptome sequencing, provides a high-resolution and global view of the cancer genome. Coupled with powerful bioinformatics tools, NGS promises to revolu
The wide application of next-generation sequencing (NGS), mainly through whole genome, exome and transcriptome sequencing, provides a high-resolution and global view of the cancer genome. Coupled with powerful bioinformatics tools, NGS promises to revolutionize cancer research, diagnosis and therapy. ...
Next-generation sequencing (NGS) technologies including DNA sequencing and RNA sequencing provide "omics" approaches to reveal genomic, transcriptomic, and epigenomic landscapes of individual cancers. A variety of genomic aberrations can be screened simultaneously, such as common and rare variants, structur...
Next-generation sequencing (NGS) is a high-throughput methodology that enables rapid sequencing of the base pairs in DNA or RNA samples. Supporting a broad range of applications, including gene expression profiling, chromosome counting, detection of epigenetic changes, and molecular analysis, NGS is ...
VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research VarDict 原文链接 MATERIALS AND METHODS 1.Local realignments and InDel calling VarDict 通过局部重对齐(包括有监督的和无监督的)提高InDel的等位基因频率统计。有些InDel比read的长度或者核心部分短很多,导致大多数...
As a result of multiple technological and practical advances, high-throughput sequencing, known more commonly as “next-generation” sequencing (NGS), can now be incorporated into standard clinical practice. Whereas early protocols relied on samples that