et al. Nanobodies® as inhaled biotherapeutics for lung diseases. Pharmacol. Ther. 169, 47–56 (2017). CAS PubMed Google Scholar Detalle, L. et al. Generation and characterization of ALX-0171, a potent novel therapeutic nanobody for the treatment of respiratory syncytial virus infection. ...
largely dominated by bacterial community, plays a significant role in the health status of the host. The healthy gut microbiota fulfills several vital functions such as energy metabolism, disease protection, and immune modulation. Dysbiosis, characterized by microbial...
), adding to the body of evidence suggesting that miliary nemaline bodies are a good indicator suggesting KLHL40 as the causative gene. Fig. 1 Pedigrees for families in which mutations were identified from next generation sequencing of a proband. Pedigrees and segregation of the mutation/s ...
Even if the degradation products could be metabolized, a high concentration of extra metabolites entering metabolism system could still pose strong side effects upon human bodies. Second, administration at the inflammation site will lead to higher degradation rate, compared with healthy tissue [119]. ...
In this Perspective, we describe the blueprint for transitioning from the current, clinical symptom-focused and inherently late-stage diagnosis and management of AD to the next-generation pathway that incorporates biomarker-guided and digitally facilitated decision-making algorithms for risk stratification,...
The regulatory environment is also evolving to support the swift introduction of innovative cancer treatments like NGDCs. Regulatory bodies, such as the US Food and Drug Administration (FDA), are increasingly inclined to expedite the approval processes for these therapies, recognizing their potential to...
143]. This triggers retinal inflammation, characterized by yellow-white necrotic lesions interspersed with red hemorrhages along blood vessels, radiating from the posterior pole to the periphery. Diagnosis involves detecting cytomegalovirus antigen PP65, CMV-mRNA, CMV isolation, or inclusion bodies [144]...
143]. This triggers retinal inflammation, characterized by yellow-white necrotic lesions interspersed with red hemorrhages along blood vessels, radiating from the posterior pole to the periphery. Diagnosis involves detecting cytomegalovirus antigen PP65, CMV-mRNA, CMV isolation, or inclusion bodies [144]...
V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel negative checkpoint receptor (NCR) primarily involved in maintaining immune tolerance. It has a role in the pathogenesis of autoimmune disorders and cancer and has shown promising
A total of 25 blastocysts were biopsied and detected during four PGT cycles and 5 polar bodies were involved in one cycle additionally. For each couple, a wild-type embryo was successfully transplanted and confirmed by prenatal diagnosis, resulting in the birth of four healthy infants.#Mosaic ...