The field of bioelectronic medicine has advanced rapidly from rudimentary electrical therapies to cutting-edge closed-loop systems that integrate real-time physiological monitoring with adaptive neuromodulation. Early innovations, such as cardiac pacemakers and deep brain stimulation, paved the way for these...
Next Generation Sequencing (NGS) has revolutionized nearly every field of genetics, but few have profited from it as much as ancient DNA research. NGS has increased the amount of DNA sequence data available from extinct organisms by several orders of magnitude and is extensively used in phylogenet...
In subject area: Biochemistry, Genetics and Molecular Biology Metagenomic next-generation sequencing (mNGS) is an unbiased approach to identify all the microbial genomes present in a clinical sample through brute-force sequencing and can detect viruses in parallel with other organism types [10...
271Citations 772Altmetric Metrics Abstract Recently, advances in wearable technologies, data science and machine learning have begun to transform evidence-based medicine, offering a tantalizing glimpse into a future of next-generation ‘deep’ medicine. Despite stunning advances in basic science and techn...
Polycystic ovary syndrome (PCOS) is a reproductive endocrine disorder. The specific molecular mechanism of PCOS remains unclear. The aim of this study was to apply a bioinformatics approach to reveal related pathways or genes involved in the development
Treangen TJ, Salzberg SL: Repetitive DNA and next-generation sequencing: computational challenges and solutions. Nat Rev Genet. 2012, 13: 36-46. CAS Google Scholar Cooper GM, Shendure J: Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data. Nat Rev Gen...
Students enrolled in the HannoverGEN classes would learn to use molecular biology tools typically reserved for college-level or graduate school courses in order to study plant genetics. Some of the basic experiments involved isolating DNA from cabbage or how learning how bacteria transfer genes to ...
43. Gen Y, Yasui K, Zen Y, Zen K, Dohi O, Endo M, Tsuji K, Wakabayashi N, Itoh Y, Naito Y, Taniwaki M, Nakanuma Y, Okanoue T, Yoshikawa T: SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma. Cancer...
Changes in viral profiles with age can occur due to environmental factors, genetics, and epigenetics. The gut virome consists of two main elements: temperate phages integrated within bacterial genomes and viromes as free virions or particles. Taxonomical classification through sequence-based analysis ...
A reasonably thorough table of next-gen-seq software available in the commercial and public domain Integrated solutions *CLCbio Genomics Workbench-de novoand reference assembly of Sanger, Roche FLX, Illumina, Helicos, and SOLiD data. Commercial next-gen-seq software that extends the CLCbio Main Wo...