Fig. 2. Following intravenous, intracerebral, and intraperitoneal injection, MSC-EVs enter systemic circulation, cross the blood-brain barrier, and reach the brain. Created with BioRender.com. 3.3. Amyotrophic lateral sclerosis (ALS) The application of MSC-secretome and EVs in ALS is recent, with...
8. It is still unclear why EVs are abundant (at least based on the detection of enriched proteins such as Alix and TSG101) in bodily fluids that can be secreted (e.g., breast milk, saliva and urine) and relatively depleted in internal bodily fluids (e.g., blood, cerebrospinal fluid)...