In the Origin of Maize Controversy, the Orthodox Teosinte Hypothesis (OTH; Beadle 1939, 1972; Iltis 1971), five key mutations change 2-ranked (distichous) ears of teosinte (wild Zea) with a single row of grains per rank to 4- to many-ranked (polystichous) maize ears with a double ro...
and many other mRNA vaccines or drugs are presently under evaluation in clinical trials [2,3]. The first mRNA vaccines were rapidly developed to meet the worldwide need for prevention of COVID
The theme of the World TB Day 2021, commemorated each year on March 24, was “The Clock is Ticking”, thus sounding an alarm signal that the fight against tuberculosis is not achieving the expected progress [2]. This is particularly true in the context of the COVID-19 pandemic, which ...
Increment in viral transmission gives more opportunity for SARS-CoV-2 mutations to arise. As a result, the only way to halt the pandemic is for safe and effective vaccines against circulating variations to be disseminated evenly worldwide. The current scenario is like all high-income countries ...
Vertex and Exonics Therapeutics have entered into a definitive agreement under which Vertex will acquire privately held Exonics, a company focused on creating transformative gene editing therapies to repair mutations that cause DMD and other severe neuromuscular diseases. “Through the expanded...
mpox cases, the median age of individuals was 22 years, 51.9% were female and 29% were sex workers, suggesting a potential role for sexual transmission. The predominance of APOBEC3-type mutations and the estimated emergence time around mid-September 2023 imply recent sustained human-to-human...
The genetics of RCC is distinctive in that in addition to mutations in VHL, these tumours have infrequent somatic mutations in known common cancer genes, such as p53 and RAS (Dalgliesh et al, 2010). Three other tumour suppressor genes have been implicated in the development of ccRCC; poly...
Michael J. Cox& Miriam F. Moffatt Abstract Lung diseases caused by microbial infections affect hundreds of millions of children and adults throughout the world. In Western populations, the treatment of lung infections is a primary driver of antibiotic resistance. Traditional therapeutic strategies have...
One of the world's largest gas-fired combined cycle power plants is to be built in Saudi Arabia, with enough capacity to supply around one tenth of the country's current power demand. The 4 GW IPP Quaryyah plant is scheduled for completion in 2014 and is being built by a consortium of...
The mutation rates of 16,677 years, 7,884 years and 3,624 years per mutation were used for HVS-I (16,051–16,400), coding region (577–16,023) synonymous mutations and entire mtDNA genome, respectively56. For Bayesian and maximum likelihood, the haplogroups with whole mtDNA genome data...