Building a zebrafish toolkit for investigating the pathobiology of epilepsy and identifying new treatments for epileptic seizures[J] . Vincent T. Cunliffe.Journal of Neuroscience Methods . 2015Cunliffe, V. T., 2016 Building a zebrafish toolkit for investigating the pathobiology of epilepsy and ...
18, 339–343 (2015). Article CAS PubMed Google Scholar Löscher, W. & White, H. S. Animal models of drug-resistant epilepsy as tools for deciphering the cellular and molecular mechanisms of pharmacoresistance and discovering more effective treatments. Cells 12, 1233 (2023). Article PubMed...
If we can find agents that can control presynaptic release, and do so even after development of epilepsy when release is enhanced, we would have a whole new class of treatments to help the 40% of epileptic patients who do not respond to any current therapeutics.E. R. Garrido...
Anticonvulsant drugs are first-line treatments for both bipolar mood disorder and epilepsy; however, few studies have explored treatment options when these disorders co-occur. The aim of this study was to identify bipolar disorder symptoms common in pediatric epilepsy and to determine whether anticonvul...
Meaning Despite availability of many new antiepileptic drugs with differing mechanisms of action, outcomes in newly diagnosed epilepsy have not improved; developing new disease-modifying compounds to current add to seizure-suppressing drug treatments may be necessary. Abstract Importance A study published ...
In conclusion, several new promising routes are being developed to ameliorate existing therapies for CDS, and to find new treatments for the so far challenging CTD (Table 3). These new strategies may involve the use of the nose-to-brain delivery, pharmacochaperones as well as gene therapy thro...
“We hope in this way to develop long term treatments that induce lung tissue repair in the patients.” In the future, the research team believes their findings can contribute to drug development and mechanistic studies in patient derived lung tissue. Eventually, they hope their discovery will ...
Therefore, in our study, affected individuals should be given 1 mg or 5 mg of vitamin B12 intramuscularly every day for five days, followed by an assessment of the production of related metabolites to judge whether the treatments were effective. For example, an improvement in clinical symptoms ...
All other treatments will be allowed. Provisions for post-trial care Any patients who suffer harm from trial participation will be covered by the Japanese public healthcare system. Clinical assessments On enrollment in this trial, clinical research physicians will obtain information from the patients ...
We have developed new models to facilitate discovery of curative treatments for toxoplasmosis. We have characterized the Brazilian T. gondii isolate called EGS that was known to be morphologically similar to encysted bradyzoites in tissue culture. We further validate the cystic nature of these EGS ...