PKD is an incurable condition for which new treatments are urgently needed. If effective medications to reduce the rate of fluid buildup in cysts could be developed, they might provide an entirely new approach to treatment to slowing the progression of the disease. The results show that CFTR pl...
STAT6—a potential new drug target for treatment of PKDResearchers have found that signal transducer and activator of transcription (STAT)6 is aberrantly activated in renal cysts of mouse models of polycystic kidney disease (PKD). STAT6 is usually inactive, but activation of this protein induces ...
New research from Yale School of Medicine has discovered that the gene Glis2 is a component of PKD signaling and may also be a new target for the treatment of the disease. The paper, "Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease...
The rapid development of surgery, first the 1980s, a number of new treatment technologies have 翻译结果2复制译文编辑译文朗读译文返回顶部 Rapid development of the first century after the 80 's, some new treatment technologies have been 翻译结果3复制译文编辑译文朗读译文返回顶部 Rapid development of ...
The seasonality of proliferative kidney disease (PKD) in rainbow trout, Salmo gairdneri Richardson, at the American River Hatchery, California was found to... JS Foott,RP Hedrick - 《Journal of Fish Biology》 被引量: 386发表: 1987年 Identification and characterization of thrombospondin-4, a ne...
Combinations of inhibitors of the renin–angiotensin system with calcium channel blockers for the treatment of hypertension: focus on perindopril/amlodipine inhibitor of the renin鈥揳ngiotensin system (RAS) and a calcium channel blocker (CCB) is a rational approach to achieve blood pressure (BP) ...
Therefore, single-cell sequencing technologies were widely used in the research of various tumors, and were of great significance for the development of new diagnostic and anti-tumor treatment methods (Fig. 2). Fig. 2 The clinical applications of single-cell sequencing in different fields, like ...
Drug-coated balloon (DCB) angioplasty has shown promise in the treatment of mature AVF stenosis. These balloons are coated in paclitaxel, which is currently approved for AV access. This device inhibits smooth muscle remodeling and fibrosis, blocks the cell cycle during mitosis, a...
In 2006, based on Weimbs' findings, Leamon began taking regular rapamycin for his diseased kidneys, with the permission of his doctor. The treatment was ineffective, and he eventually had kidney failure. In 2010, he underwent a kidney transplant, thanks to the donation of his sister's kidney...
The results also suggest that in patients, treatment with 11beta compounds once every few months, or even once a year, could significantly delay disease progression, and thus avoid the need for continuous, burdensome antiproliferative therapies such as tolvaptan. ...