There have been major advances in the immunotherapy of cancer in recent years, including the development of T cell engagers — antibodies engineered to redirect T cells to recognize and kill cancer cells — for the treatment of haematological malignancies. However, the field still faces several chal...
The use of this therapy in the last few years has been successful, with a reduction in remission rates of up to 80% for hematologic cancer, particularly for acute lymphoblastic leukemia (ALL) and nonHodgkin lymphomas, such as large B cell lymphoma. Recently, antiCD19 CAR therapy, or UCART...
BioMed X and the Universitätsmedizin Mannheim (UMM) announced the publication of two manuscripts in the field of cancer immunology in the journalScience Advances. The main objective of the collaboration was to understand the role of specific T cell responses in a patient with an aggressive subty...
T cell-mediated adaptive immune response is controlled by both positive costimulation and negative coinhibition, generated mainly by the interaction between the B7 family and their receptor CD28 family. Coinhibition is exploited by prostate cancer as an immune evasion pathway. Overexpression of coinhibit...
Table 1. Characteristics of Phase 3 Cancer Treatment Clinical Trials at SWOG View LargeDownload Table 2. Cost Estimates for New Drug Approval in the Pharmaceutical Industrya View LargeDownload Supplement. eTable 1. Description and Key Findings of the 82 Practice-Influential Phase 3 Cancer Treatment...
24 in Nature reveal the structure of this molecule, opening new paths for cancer treatment development. The ALK molecule is a receptor — a protein that sits in the membrane of a cell and responds to other molecules that bind to it — found primarily in the brain and centra...
Chimeric antigen receptor (CAR)-T cell adoptive immunotherapy is a promising cancer treatment that uses genetically engineered T cells to attack tumors. However, this therapy can have some adverse effects. CAR-T cell-derived exosomes are a potential alte
Mini Cell Treatment Brings New Hope to Cancer SufferersGoodchild, Sophie
The results of this study could change the direction of research into cancer stem cell biology and stimulate the search for new authentic cancer stem cell markers, the researchers say. "The origins of primary and metastatic tumors are decidedly not the same, and we must broaden our thinking bey...
10th Anniversary of Cancers—Targeted Therapies for Ovarian Cancer Treatment from Bench to Bedside3rd Etnean Occupational Medicine Workshop—Breast Cancer and Work3D Cell Culture Cancer Models: Development and ApplicationsA Deeper Dive into Signaling Pathways in CancersA Selection of Papers from the ...