This complexity was recently reflected in the newest American Joint Committee on Cancer (AJCC) breast cancer staging, implemented in 2018. Although it seems very daunting, the new staging is based on both the anatomical extent of the disease and the prognostic factors such as hormonal and HER2 ...
Summary Progress in the treatment of breast cancer developed along multiple directions of research during the last decade. The concept of dose-intensity was addressed through retrospective analyses and prospective randomized trials. It was confirmed that dose-intensity correlates with higher response rates,...
In a study reported in theJournal of Clinical Oncology,Jennifer K. Plichta, MD, MS, and colleagues formulated a novel prognostic staging system for de novo metastatic breast cancer. Study Details The staging system was developed using data from 42,467 patients from the National Cancer Database...
LABC locally advanced breast cancer; mBC metastatic breast cancer; mESR1 estrogen receptor 1 gene mutated; mo months; mPFS median progression-free survival; mPI3Ki phosphoinositide 3-kinase inhibitors; mTORi mammalian target of rapamycin inhibitors; n/a not available; ORR objective response rate; ...
This study underscores the potential of multimodal data integration in enhancing breast cancer staging and offers insights into leveraging deep learning models for generating and classifying histopathological data, alongside identifying novel disease stages. 展开 ...
Nanotechnology plays a role at all stages of lung cancer diagnosis and treatment. a) Nanotechnology promotes early screening of lung cancer. b) Nanotechnology facilitates lung cancer diagnosis and staging. c) Nanotechnology promotes lung cancer therapy. d) Nanotechnology promotes the detection of minimal...
CanStaging⁺, a user-friendly tool aimed at facilitating the recording of comparable cancer staging data worldwide, has been launched.
3. staging and extent of disease (relevant for prognosis). 4. in case of metastasis of occult primary tumor: differential diagnosis of possible primary tumor. 4. giving insight in histogenesis and tumor biology. Especially in the last decade a large number of polyclonal and monoclonal antibodies...
Chen et al. investigated proteomic trends within LCNS tumors and explored how this data correlated with genomic and transcriptomic findings. Clustering the tumors by proteomic profile led to three subgroups that were separated by tumor staging. This division by disease stage was not present when clus...
In breast cancer, downregulated circ-Foxo3 can enhance cell survival and decrease cell apoptosis [52]. In bladder cancer, circPTK2 is highly expressed among fourty pairs of tissues and blood specimens, and its expression level is significantly associated with lower differentiation, N2-N3 lymphatic ...