Around one-third of men with erectile dysfunction don’t respond to PDE5 inhibitors such as sildenafil. Lybrido and Lybridos may have potential in this group, particularly if the issue is a result of low sensitivity to sexual cues or an overactive sexual-inhibition system. Other potential ther...
Penile erection is a neurovascular process controlled by numerous tightly regulated events, and occurs in response to the activation of pro-erectile autonomic pathways. It is dependent on an adequate inflow of blood to the erectile tissue through both en
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Currently, severe erectile dysfunction can be treated by intracavernous injections of solutions containing three active ingredients: prostaglandin E1 (PGE1), papaverine and urapidil. Very few data exist on this mixture where phentolamine has been replaced by Urapidil because Phentolamine is not used ...
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mammalian and avian divers, and the many distinct aspects of reptile physiology, particularly ectothermy and flexible vascular circulation [9], might lead to different adaptive solutions. In these respects, marine reptiles are important taxa for advancing genomic studies of aquatic adaptations in ...
Since Discovery is contributing with, for exam- ple, translational science and safety assessment, we need to provide solutions together with our Development colleagues to satisfy regulators. However, I do feel that the regulators and the media need to appreciate that the issue is ben- efit ...