Other types of molecules, or modalities, are therefore required to address these targets, which has led several academic research groups and pharmaceutical companies to increasingly use the concept of so‐called “new modalities”. This Review defines for the first time the scope of this term, ...
Despite the challenges involved in commercially manufacturing mRNA therapeutics successfully, CDMOs are investing in the capabilities to manufacture emerging mRNA product modalities to help stay ahead of pharma’s renewed mRNA development curve. Why mRNA has potential One aspect that makes mRNA technology ...
Cancer survival gains will result from improved curative treatment2, and among those cancer patients who are cured, it has been estimated that 49% are cured by surgery, 40% by radiotherapy alone or com- bined with other modalities, and 11% by chemotherapy alone or combined with other ...
At present, the predominant theory regarding the cause of AD is the amyloid hypothesis; crucial advancements in AD therapy have been made on the basis of the proposed role of amyloid accumulation in the AD development. The United States Food and Drug Administration (US FDA) granted traditional ...
Generative AI, or Artificial Intelligence Generated Content (AIGC), which is popular in China, is the first phenomenal application of AI 2.0. AI 2.0 models can learn from data of multiple modalities including text, image, voice, video, and even DNA or proteins to construct different levels of...
drug delivery systems. Some studies have attempted to enhance yield or purity through electrophoresis [29], size exclusion [25], antibody capture [30], and polyethylene glycol (PEG) co-precipitation [22], although these methods are not mainstream. In this review, the focus is primarily on the...
INTRODUCTION:Although surgery, chemotherapy, and radiotherapy are important cancer treatment modalities, they possess some limitations; for example, theiruse is limited in the case of end-stage cancer patients who may notsurvive intensive chemotherapy. Therefore, adjunctive therapy issometimes used in ...
The reason for not obtaining any response to antituberculous treatment in drug-resistant tuberculous cases is the presence of the cavitary lesion. Because of the treatment difficulties in drug-resistant tuberculous (DRTb) and of the surgical complications, many new treatment modalities have been develo...
This review provides a comprehensive clinical update for DKD in people with type 2 diabetes, with a special focus on new treatment modalities. The traditional strategies for prevention and treatment of DKD, i.e., glycemic control and blood pressure management, have only modest effects on minimizing...
In the absence of regulatory guidelines for the bioanalysis of new drug modalities, many of which contain multiple functional domains, bioanalytical strate