The localization of creatine kinase (ATP-creatine phosphotransferase) in growing long bones of new-born mice was studied histochemically. Its activity was found to vary within and between different areas of the cartilagenous epiphyses of proximal tibia. Chondrocytes in the cartilaginous epiphysis showed...
Another drug approved by the FDA for breast cancer via priority review in 2023 iscapivasertib. Capivasertib is a first-in-class, selective, highly potent ATP-competitive pan-AKT kinase (protein kinase B) inhibitor with similar activities against the three isoforms AKT1, AKT2, and AKT3 (Andr...
Lundin A, Lindberg K, Nordlander R, Nyquist O, Styrelius I (1979b) Determination of creatine kinase B-subunit activity by continuous monitoring of ATP: a new bioluminescent technique applied in clinical chemistry. In: Schram E, Stanley P (eds) Proceedings: international symposium on analytical ...
[2]. During ischemia, due to the intimate relationship between oxygen supply and coronary blood flow, normal perfusion to the cardiomyocyte is interrupted, leading to the termination of aerobic metabolism, creatine phosphate depletion, and anaerobic glycolysis, causing mitochondrial dysfunction [3]. ...