Examples of new multimodal mesothelioma treatments include: Hyperthermic intrathoracic chemotherapy (HITHOC): This treatment allows doctors to deliver chemotherapy drugs directly into the chest cavity during pleurectomy and decortication (P/D) surgery, which involves removing the lining of the lung (pleu...
Promising Investigational New Drugs for Mesothelioma: What Is the Next Stage of the Treatment for Advanced Mesothelioma?Inter-patient heterogeneity is a major barrier to achieving the effective therapy of mesothelioma. Recent advances in genomics have illuminated the extent of genomic inter-patient ...
Opdivo (nivolumab) is a programmed death receptor-1 (PD-1) blocking antibody for the treatment of melanoma, non-small cell lung cancer, malignant pleural mesothelioma, renal cell carcinoma, classical Hodgkin lymphoma, squamous cell carcinoma of the head and neck, urothelial carcinoma, MSI-H or ...
(11) In practice, given the absence of a better alternative, and pending the results of a second trial, the cisplatin + pemetrexed combination can be used as a first-line regimen for patients with pleural mesothelioma. However, pemetrexed cannot replace docetaxel in second-line treatment of non...
The development of new anticancer agents is one of the most rapidly changing aspects of cancer research. Investigational New Drugs provides a forum for the rapid dissemination of information on new anticancer agents. The papers published are of interest
Diffuse malignant peritoneal mesothelioma (DMPM) has traditionally been regarded as a rapidly lethal tumor, and its biology remains largely unknown. In recent years, understanding of the genetic and molecular mechanisms of DMPM has considerably increased, as have the treatment options. Several independent...
Clinical activity was observed with an overall disease control rate of 35% and 4 confirmed responses in mesothelioma, ovarian cancer, atypical lung neuroendocrine tumour, and intrahepatic cholangiocarcinoma. Across all tumours, multimodal analyses of paired patient biopsies pre- and post-treatment ...
Significant advancements have been made in the application of chimeric antigen receptor (CAR)-T treatment for blood cancers during the previous ten years. However, its effectiveness in treating solid tumors is still lacking, necessitating the exploration
The standard treatment for pleural mesothelioma is currently surgery to remove the patient's lung - a potentially debilitating consequence. "Current surgical and chemotherapy treatments of patients with malignant pleural mesothelioma are unsatisfactory, and have not been shown to significantly prolong surviva...
13.Use of the composition of claim 1 for the manufacture of a medicament for the treatment of one or more diseases involving mucin or for the treatment of one of more diseases involving thrombi. 14.A method for the treatment of one or more diseases involving mucin or for the treatment of...