Eosinophilic asthma is identified in primary care by having eosinophils ≥150–300 cells/μL on a complete blood count with differential. Conclusions: A new class of agents is available for patients with moderate to severe eosinophilic asthma. Four biologic therapies – mepolizumab, reslizumab, ...
"What we saw in these studies were that the eosinophils went away on the biopsies, so the medication was working biologically, but there were still other persistent changes when you look under the microscope that didn't get better," explained Dellon. "And when you look at the esophagus, it...
Remission in asthma is an incredible achievement. However, it is not a cure. With the right treatment as early in their treatment journey as possible, some patients will achieve remission. Although free from exacerbations and the need for OCS, the right medication or combination of medicines coul...
(Fig. 6E). Among the top-ranking pathway, the RAGE pathway was regarded as the focus of attention, as RAGE signaling are involved in dendritic cell-T-cell cross-talk [46], and plays a central role in the pathogenesis of eosinophilic asthma [47]. The members of the NF-κB family are ...
“This paper is about fear. Systems pharmacology model enables us to explain that one shouldn’t be afraid of high blood eosinophilic count while taking anti-Interleukin 13 medication. Moreover we managed to provide mathematical ar...
Defining and targeting mechanisms of eosinophilic inflammation in a new era of severe asthma treatment doi:10.1172/JCI182410Journal of Clinical InvestigationJoshua A. BoyceStephanie C. Eisenbarth
SLIT, the evidence is low to support SCIT over SLIT for improving asthma or rhinitis symptoms or medication usage [26]. Safety of pediatric SLIT Although there had already been several reports of eosinophilic esophagitis as an adverse reaction secondary to oral immunotherapy with certain foods [30...
Angiotensin-(1–7) promotes resolution of eosinophilic inflammation in an experimental model of asthma Front. Immunol., 9 (2018), p. 58 View in ScopusGoogle Scholar [137] Y. Meng, C.H. Yu, W. Li, T. Li, W. Luo, S. Huang, P.S. Wu, S.X. Cai, X. Li Angiotensin-converting ...
possible occupationally induced asthma and prescribed asthma medication were collected from hospital clinics, primary health care, occupational health care and private practices for the whole 12-year follow-up period. In addition, the use of medication that was realised, i.e., medication bought from...
been found in a study that enrichment of Mycobacterium avium upregulated intratumoral LPS, which subsequently promoted prostate cancer progression and docetaxel resistance through activation of the NF-κB-IL6-STAT3 signaling axis.295Tamoxifen is a commonly used endocrine medication for breast cancer, and...