the application of various nanomaterials and microfluidic technologies in CTCs enrichment technology has assisted to improve our deep insights into the phenotypic characteristics and biological functions of CTCs as a potential therapy target, which may pave the way for us to make practical clinical...
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis, ectopic calcification, herniation, or mixed phenotypes. Amongst
as life scientists have widely acknowledged the ability of three-dimensional (3D) in vitro culture systems to accurately simulate in vivo biology. In recent years, researchers have discovered that microgravity devices can address many challenges associated with 3D cell culture. Stem cells, being...
Novel Insights into the Relationship between Diabetes and Osteoporosis obesityleptinosteocalcinKnowledge about the influence of bone on intermediary metabolism corresponds to a developing area that has gained prominence. The old ... FJAD Paula,MC Horowitz,CJ Rosen - 《Diabetes》 被引量: 198发表: 2010...
Other proteins like osteocalcin and low-density lipoprotein receptor-related protein 5 (Lrp5 receptor), a member of LDL family, are also up-regulated indicat- ing an endochondral ossification process in MMV [6]. Moreover, a genetic study showed a specific mutation in the filamin-A gene ...
This research revealed that metformin could increase the expression of osteogenic genes such as bone sialoprotein, alkaline phosphatase, Runx2, osteocalcin, and SHP. Metformin induces the physical interaction and the formation of a complex between SHP and Runx2 in the osteocalcin promoter. The ...
Pre-osteogenic cells derived from mesenchymal stem cells have the ability to differentiate into osteoblasts. This differentiation process is regulated by various growth factors, including RUNT-related transcription factor 2 (Runx2), osterix (Osx), osteopontin (OPN), osteocalcin (OCN), and bone morphog...
et al. Large-scale association analysis of the Metabochip provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. published online (12 August 2012); doi:10.1038/ng.2383. Speliotes, E.K. et al. Association analyses of 249,796 individuals reveal 18 ...
Studies of SCFAs in bone formation have mainly focused on butyrate. After treatment with butyrate, mice exhibited a substantial increase in BV/TV, serum osteocalcin (OCN), and mineral apposition rate (MAR) after two and four weeks compared to those treated with a control vehicle.33The increase...
The outcome of viral infections can be highly variable depending on the pathogenic nature of the virally encoded genes, interactions between the virus and the host immune system and the ability of the virus to replicate and/or induce latency following infection. Insights into the mechanisms of vir...