This information on melatonin absorption behaviors and its modulation by pharmaceutical excipients can be used in further oral dosage formulations to affect circadian rhythm.doi:10.1016/j.ijpharm.2009.05.024Huyen Thi Thanh TranPhuong Ha Lien Tran...
In human beings, melatonin is secreted in a cyclic way by the pineal gland, although it has been detected in other tissues. Synthesis of melatonin takes place in the pinealocyte. It depends on adrenergic stimulation, and its secretion is related to the photoperiod in a circadian model of low...
2 (and in Supplementary Fig. 1 in Supplementary Information), where standard error of the means (SEM) are shown. The Wilcoxon signed-rank test for paired samples was used to compare mean melatonin and 6-SMT concentrations at each time point of the kinetics to basal concentrations. The ...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.doi:10.1002/chin.200634113Jean A. Boutin
220 EFFECTS OF MELATONIN AND PENTOXYPHILLINE TREATMENT ON NEWBORN RAT MODEL OF HYPOXIC ISCHEMIC ENCEPHALOPATHY O. Soz1, M.K. Turkmen1, A. Kumral2, B. Baykara2, D.C. Yesilirmak2, H. Baskin2, O. Yilmaz2 1Adnan Menderes University, Aydin, 2Dokuz Eylul University, Izmir, Turkey ...
In vitro, melatonin increased the number of new neurons derived from adult hippocampal neural precursor cells in vitro by promoting cell survival. This effect was partially dependent on the activation of melatonin receptors as it could be blocked by the application of receptor antagonist luzindole. ...
cryopass-laser therapy could be an effective method to transdermal delivery of melatonin to the site of action without causing pain [63]. To prove melatonin effectiveness in prostate cancer therapy, further studies are needed. Table1; Fig.1summarize present information of melatonin therapy for prost...
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More commonly known as the sleep hormone, melatonin also has antioxidant, anti-inflammatory, antiapoptotic, and many other crucial properties2,3. In mammals, this multitasking indolamine is synthesized in the pineal gland in a circadian manner in response to the photoperiodic information received via...
The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that exert a profound influence on tumor initiation and progression. Within the TME, angiogenesis is predominan