Dementia in general and Alzheimer's disease in particular represent conditions where new findings are being made rapidly. Some of these developments will lead to progress of increasing clinical value to patients and their carers. This review will begin with some general points about dementia before ...
so they spend their time reminiscing about their worst memories of the holiday with Sophia. The matriarch recounts one of the worst Valentine's in history—the St. Valentine's Day Massacre of 1929—which she claims to have witnessed while being stranded in Chicago. ...
Alzheimer’s disease (AD) is the most common neurodegenerative disease1, with a prevalence of more than 50 million cases worldwide in 2015, a number that is expected to reach 135 million in 2050. After more than a century of intensive research, the causes of AD are still largely unknown a...
Life most likely developed under hyperthermic and anaerobic conditions in close vicinity to a stable geochemical source of energy. Epitomizing this conception, the first cells may have arisen in submarine hydrothermal vents in the middle of a gradient es
Alzheimer’s disease25. Recent studies in glaucomatous human postmortem samples and in rat models identified oxidative inactivation of serpins (neuroserpin) as a molecular mechanism of increased plasmin activity leading to neurodegeneration in high ocular pressure conditions26. In the trabecular meshwork,...
From1981-2005,theCDC“estimated”thenumberofHIV/AIDScases(diagnoses,deaths,andpersonslivingwithAIDS)tobe~1million(956,666) Thisisa0%increase Attheendof2003,theCDCrevisedtheirestimates–thenumberofHIV/AIDScases(diagnoses,deaths,andpersonslivingwithAIDS)isestimatedtobebetween1,039,000to1,185,000 Onthesur...
Cancer, ranked as the second leading cause of mortality worldwide, leads to the death of approximately seven million people annually, establishing itself as one of the most significant health challenges globally. The discovery and identification of new a
(Bio-Si) could be used alongside more conventional redox and paleo-productivity proxies to study the distribution of OM in marine sediments. The qualitative and quantitative study of palynological OM provides more detailed information on the nature of sedimentary organic carbon, which can be helpful ...
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Alzheimer’s disease (AD) is the most common type of dementia which causes memory, thinking, and behavioral problems. Improper subcellular locations of various transcription factors and signaling proteins and karyopherins have been identified in the neurons of the AD brain. In AD brain neurons, the...