Dementia in general and Alzheimer's disease in particular represent conditions where new findings are being made rapidly. Some of these developments will lead to progress of increasing clinical value to patients and their carers. This review will begin with some general points about dementia before ...
Alzheimer’s disease (AD) is the most common neurodegenerative disease1, with a prevalence of more than 50 million cases worldwide in 2015, a number that is expected to reach 135 million in 2050. After more than a century of intensive research, the causes of AD are still largely unknown a...
both associated with ONH morphology via CPASSOC multi-trait analysis.SERPINE3belongs to the clade E family of extracellular serpins. Family members have been described to play a role in other neurodegenerative diseases such as Alzheimer’s disease25. Recent studies in glaucomatous ...
This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filaments from Alzheimer's and Pick's disease inclusions, as well as the structure of the repeat regions of tau bound to microtubules. Tau structure covers various species as ...
Life most likely developed under hyperthermic and anaerobic conditions in close vicinity to a stable geochemical source of energy. Epitomizing this conception, the first cells may have arisen in submarine hydrothermal vents in the middle of a gradient es
Other intermediates, 1a–b and 1-(4-bromobutyl)-3-(1H-indol-3-yl)pyrrolidine-2,5-dione (2g), as well as 3-piperidin-4-yl-1H-indole (3a–c) and 3-piperidin-3-yl-1H-indole derivatives (5a–c) were synthesised according to previously described procedures (for more information see ...
From1981-2005,theCDC“estimated”thenumberofHIV/AIDScases(diagnoses,deaths,andpersonslivingwithAIDS)tobe~1million(956,666) Thisisa0%increase Attheendof2003,theCDCrevisedtheirestimates–thenumberofHIV/AIDScases(diagnoses,deaths,andpersonslivingwithAIDS)isestimatedtobebetween1,039,000to1,185,000 Onthesur...
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of the most complex and sophisticated concierges that defend the central nervous system (CNS) by numerous mechanisms. While they maintain the neuro-ecological homeostasis through the regulated entry of essential...
Alzheimer’s disease (AD) is the most common type of dementia which causes memory, thinking, and behavioral problems. Improper subcellular locations of various transcription factors and signaling proteins and karyopherins have been identified in the neurons of the AD brain. In AD brain neurons, the...
Network analysis of neuropsychiatric symptoms in Alzheimer’s disease Grace J. Goodwin Stacey Moeller Samantha E. John Alzheimer's Research & Therapy(2023) Scientific Reports (Sci Rep)ISSN2045-2322(online) Sign up for theNature Briefing: AI and Roboticsnewsletter — what matters in AI and robotics...