These compounds are antagonistic to androgenes receptor and cytochrome inhibitor P450 17 伪 - hydroxylase / 17.20-liasa (CYP17) and can be used in the treatment of prostate cancer.HAIKARAINEN, ANSSIKARJALAINEN, ARJAPASSINIEMI, MIKKOWOHLFAHRT, GERD...
IL: Interleukin ILi: Interleukin inhibitor iMTA: Institute for Medical Technology Assessment ITT: Intention to treat LOCF: Last observation carried forward MCQ: Medical Consumption Questionnaire NI: Non-inferior NMB: Net monetary benefit PASI: Psoriasis Area and Severity Index PCQ: Producti...
6.10. The inhibitor of Rho kinase (ROCK) ROCK is a serine/threonine kinase whose function is regulated by small G protein Rho [222]. It was reported that both of them have a significant impact on DKD occurrence [223], [224]. Xie et al. have found that the RhoA/ROCK pathway can acti...
IL13RA2 is a tumor antigen-like factor, which is highly expressed in the glioblastoma patients43. Two enriched GO terms named cell morphogenesis involved in differentiation (p = 1.24 × 10−5) and cell migration (p = 2.59 × 10−6) mainly contribute to the tumor ...
Targeting of hematologic malignancies with PTC299, a novel potent inhibitor of dihydroorotate dehydrogenase with favorable pharmaceutical properties. Mol Cancer Ther. 2019;18:3–16. CAS PubMed Google Scholar Sykes DB. The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in ...
Baloxavir marboxil is taken as a prodrug, which is converted by hydrolysis to baloxavir. Baloxavir targets the cap-dependent endonuclease activity of PA and strongly hinders viral mRNA synthesis and, as a result, replication. The use of NA inhibitors or the PA inhibitor by patients with ...
Buntanetap is a novel translational inhibitor of multiple neurotoxic proteins, including APP, tau, and α-synuclein, by enhancing the binding of the atypical iron response element in the 5′UTR regions of the mRNA of the neurotoxic proteins to iron regulatory protein 1 [62]. In February 2023...
incl. tamoxifen, trastuzumab, paclitaxel or docetaxel [63,64]. This suggests that rationale derived combination therapies using the blockade of MCL-1 can induce cell death in all breast cancer subtypes in addition to single-agent MCL-1 inhibitor approaches in tumor clones with strong MCL-1 depend...
Samples were incubated at 37°C for 30 minutes; those containing 1 IlmoliL fluoxetine or desipramine were used to de termine nonspecific binding of 3H-paroxetine and 3H-tomoxetine, respectively. After incubation, the tubes were fIltered through Whatman GF/B fIlters, which were soaked in ...
et al. Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation. Nat Med 8, 366–372 (2002). https://doi.org/10.1038/nm0402-366 Download citation Received17 December 2001 Accepted06 March 2002 Issue Date01 April 2002 DOIhttps://doi...