They also offered information on the improved drugs developed for COPD exacerbations, including antioxidants, anti-inflammatory agents and carbocisteine.HanselNationalTrevorNationalT.NationalBarnesNationalPeterNationalJ.NationalLancetHansel TT, Barnes PJ. New drugs for exacerbations of chronic obstructive ...
COPD is one of the most common diseases in the world, and there is a global increase in prevalence, but there are no drugs available at present that halt the relentless progression of this disease. However, a better understanding of the cellular and molecular mechanisms that are involved in ...
New Drug Therapies for COPD Clinical trials with new drugs for chronic obstructive pulmonary disease (COPD) have been performed. Viruses exacerbate COPD and bacteria may play a part i... CL Ross,TT Hansel - 《Clinics in Chest Medicine》 被引量: 159发表: 2014年 New anti-inflammatory therapies...
Whereas 20 years ago the most common drugs for COPD were short-acting bronchodilators, most patients are now treated with three different drugs as maintenance therapy at an annual cost of more than US$32 billion worldwide. In 2012, the bestselling prescription drug in the world was an ...
New Drugs for Asthma, Allergy and COPDdoi:10.1159/000062123Trevor T. HanselPeter J. Barnes
Despite the longstanding knowledge and understanding of the adverse effects of O3 on pulmonary biology, the use of O3 as a challenge model to assess the potential of new drugs for the prevention of acute exacerbations in COPD, is relatively new. The model has been shown to be safe and to ...
Drugs and antibodies targeting chemokines and their receptors are generally still in early stages of development and the results of clinical trial are awaited with great interest. These agents may not only provide improved management of COPD but also, importantly, indicate proof-of-concept to further...
With better understanding of the inflammatory and destructive process in the pathophysiology of COPD, several new therapeutic targets have been identified. Several mediator antagonists or inhibitors tested in COPD have so far been disappointing. Broad-spectrum anti-inflammatory drugs may be more effective...
In this review the new drugs belonging to both old and new classes of antibiotics will be analysed and discussed (Table1). Table 1New antibiotics approved and/or in development Full size table Cephalosporins The cephalosporin class of antimicrobial agents is known for its broad spectrum of activit...
New drugs for exacerbations of chronic obstructive pulmonary disease. COPD is also associated with corticosteroid resistance, abnormal macrophage and T-cell populations in the airway, autoinflammation and autoimmunity, aberrant ... TT Hansel,PJ Barnes - 《Lancet》 被引量: 165发表: 2009年 Inflammation...