Table 2 Antibody acquisition model parameter estimates. Full size table Figure 4 Best-fit antibody acquisition models. Black points denote geometric mean antibody levels in arbitrary units (AU) and vertical bars denote the 95% range of the data. Model 1: stable transmission (solid lines). Model...
Junmin Wang contributed to acquisition, analysis, interpretation and drafted the manuscript. Hongjiao Xiang and Yifei Lu contributed to acquisition and analysis. Tao Wu and Guang Ji contributed to conception and design and critically revised the manuscript. All authors gave the final approval. Conflict...
New drug delopment by United States pharmaceutical firms, with analyses, of trends in the acquisition and origin of drug candidates, 1963–79. Clin Pharmacol Ther 1982: 32: 407–17Wardell, W., May, M. and Trimble, G. 1982. New drug development by United States pharmaceutical firms. ...
Arguably the most well studied model of ADHD is the spontaneously hypertensive rat (SHR), which has shown hyperactivity, impulsivity, and inattention17. However, the SHR is limited in two important aspects: 1) the model was selectively bred for hyper- tension, therefore it is difficult to ...
Acquisition, analysis, or interpretation of data: Peahl, Dalton, Lai, Hu, Waljee. Drafting of the manuscript: Peahl, Montgomery, Lai, Waljee. Critical revision of the manuscript for important intellectual content: All authors. Statistical analysis: Peahl, Lai, Hu. Administrative, technical, or...
Acquisition, analysis, or interpretation of data: Liang, Chang, C.-C. Yang, Shih, Yau, Tang. Drafting of the manuscript: Liang, Shih, Yau, Tang. Critical revision of the manuscript for important intellectual content: C.-P. Yang, Liang, Chang, C.-C. Yang, Yau, Tang, Wang. Statistical...
How could the portfolio model disrupt R&D in biotech? The impact of using the portfolio model will differ for biotech companies, pharma companies, pharma-service providers, and investors. For biotech companies, the portfolio model represents an alternative to an acquisition or IPO. Companies have tr...
acquisition. Experimental and clinical work conducted during several years led us to the conclusion that interference patterns emitted from body surfaces in response to high frequency electric impulses carry encoded information on the shapes, densities, complexity and dynamic features of the most ...
Mouse models are essential to study and comprehend normal and malignant hematopoiesis. The ideal preclinical model should mimic closely the human malignancy. This means that these mice should recapitulate the clinical behavior of the human diseases such as cancer and therapeutic responses with high repro...
it could just as well reflect some of the challenges to accurate phage genome annotation, including false negatives (undetected genes) and incorrect functional annotation29,30. Gene content variation has been shown to be related to recombination events resulting in acquisition or loss of gene(s)31...