that these are as important as tics and may have the greatest impact on qualityCole, PDrugs of the Future
Here, we identify established as well as novel targets for antibodies in ovarian cancer, and discuss how they may provide fresh opportunities to identify interventions with enhanced therapeutic potential. 展开 关键词: Antibodies clinical trials immunotherapy immune checkpoint molecular-targeting ovarian ...
This Review provides an overview of haemostasis and thrombosis, details the current landscape of antithrombotic agents, addresses challenges with preventing thromboembolic events in patients at high risk and describes the emerging therapeutic strategies that may break the inexorable link between antithrombotic...
Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use Author links open overlay panelFrank H. Ebetino a b c, Shuting Sun a, Philip Cherian a, Sahar Roshandel a, Jeffrey D. Neighbors d,...
Drug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating enzymes, play a pivotal role in protein deubiquitination. As scientific research advances, USPs ha...
Low-dose drug combinations along molecular pathways could maximize therapeutic effectiveness while minimizing collateral adverse effects. Drug Discov. Today 16, 1001–1006 (2011). PubMed Google Scholar Gitelman, S. E. et al. Imatinib therapy for patients with recent-onset type 1 diabetes: a ...
new directions for the treatment of neurodegenerative disease.IUPHAR can be a partner in developing new therapeutic paradigms,by expert assessmentof complex ... Michael SPEDDING - 《中国药理学与毒理学杂志》 被引量: 0发表: 2015年 Privacy Preservation in Location-Based Mobile Applications: Research D...
Our data highlight miR-21 as a novel therapeutic target for the treatment of this form of asthma. Airway epithelial regulation of pulmonary immune homeostasis and inflammation 2014, Clinical Immunology Show abstract Recent genetic, structural and functional studies have identified the airway and lung ...
80, and protein structure prediction. However, to date, no study has focused on predicting the potential therapeutic effects of probiotic strains on various diseases. Therefore, our research aims to determine which probiotic strains have the greatest therapeutic potential for treating different diseases....
Therapeutic targeting of autophagy in neurodegenerative and infectious diseases. J Exp Med. 2015;212:979–90. Article CAS PubMed PubMed Central Google Scholar Lee MJ, Lee JH, Rubinsztein DC. Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. Prog Neurobiol. ...