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So, DESTINY-CRC02 [NCT04744831] study allows a RAS-mutant population. There was an explorational analysis of the DESTINYCRC study, which was a biomarker analysis and there were some patients who had ctDNA evidence off RAS mutations and the response rates were still seen in those patients.” ...
This offers an opportunity to alleviate the immune suppression within the tumor microenvironment (TME) and stimulate systemic immune responses during the treatment of solid tumors [6, 7]. Wang et al. demonstrated that even if pyroptosis occurs in less than 15% of cancer cells, it is still ...
After his latest film – Indiana Jones and the Dial of Destiny –flopped at the box office last year, James Mangold will hope to rebuild his reputation with a flick that feels like a shoo-in for multiple nominations on the 2025 awards circuit (based on its numerous 2025 BAFTA nominations,...
Kaklamani on Elacestrant for CDK4/6 Inhibitor-Naive ER+ Breast Cancer Treatment T-DXd in ER+/HER2-Low Breast Cancer: Insights From DESTINY-Breast06 Expanding Access to Bispecifics in R/R Multiple Myeloma Treatment Real-World Outcomes of Oral Azacitidine Maintenance in AML Presented at ASH 20...
“Besides treating patients, who are at the center of everything we do, we also have great opportunities here to advance clinical science and research,” he said. “Every day, I wake up determined and motivated in equal measure. Not a lot of people can say that, but I can.” Colorectal...
Trastuzumab deruxtecan was evaluated in DESTINY-Breast01 (NCT03248492), a singlearm phase II study that included 184 adults with HER2-positive MBC previously treated with trastuzumab and T-DM1.3,16 Most patients had also received at least 1 other systemic therapy. The objective response rate (...
TKIs revolutionized CML treatment for many years, and prolong patients’ life expectancy to be comparable to age-matched healthy individuals [5,6,7,8,9]. With significant advances in the treatment of CML, priority is placed on improving the quality of life of CML patients and on the efficacy...
A mom walks up to the District Attorney’s desk in the Justice of the Peace Court with a total of six tickets as a result of her low-income children’s truancy, three in her name and one for each of her three children. She faces the possibility of having