The most recently emerged carbapenemase is the New Delhi metallo-beta-lactamase (NDM-1). NDM-1 was named after the place (New Delhi, India) where it was assumed to have originated, similar to other nomenclature for metallo-[beta]-lactamases, Verona imipenemase (VIM), German imipenemase (...
NDM (New Delhi Metallo-β-Lactamase) is a recently discovered enzyme which has the ability to hydrolyze all β-lactam antibiotics, except aztreonam. Making that scenario more worrisome is the fact that mobile fragments of DNA carrying blaNDM genes, also keeps a number of other genes encoding ...
metallo‐beta﹍actamaseMetallo-beta-Lactamases (MBLs) are class B β-lactamases that hydrolyze almost all clinically-available β-lactam antibiotics. MBLs feature the distinctive αβ/βα sandwich fold of the metallo-hydrolase / oxidoreductase superfamily and possess a shallow active-site groove ...
New Delhi Metallo-Beta-lactamases (NDMs) are amongst some of the most worrisome and prevalent MBLs. This family of MBLs is capable of hydrolyzing all generations of bicyclic beta-lactams. Among this family, NDM-1, NDM-4, and NDM-12 are key members. To combat these proteins, an inhibitor...
New Delhi Metallo-Beta-Lactamase: Structural Insights into Beta-Lactam Recognition and Inhibition Metallo-β-Lactamases: Structural Features, Antibiotic Recognition, Inhibition, and Inhibitor Design. Wang Jing-Fang,Chou Kuo-Chen. Current Topics in ... D King,L Worrall,R Gruninger,... - 《Journal...
NDM metallo-beta-lactamases and their bacterial producers in health care settings Clin Microbiol Rev, 32 (2) (2019) Google Scholar [3] E.M.C. D’Agata Addressing the problem of multidrug-resistant organisms in dialysis Clin J Am Soc Nephrol, 13 (4) (2018), pp. 666-668 CrossrefView in...
The global dissemination of the New Delhi metallo-beta-lactamase (NDM) gene among certain strains of bacteria has serious implications since the infections caused by such organisms pose a therapeutic challenge. Although the NDM gene has been detected in various parts of the world, this is the fir...
New Delhi Metallo-β-lactamases (NDMs), Verona Integron-encoded Metallo-β-lactamases (VIMs) and Imipenemases (IMPs), have two zinc ions in active site; they are characterized by a broad substrate specificity and able to hydrolyze almost all β-lactam antibiotics with the excep...
New Delhi metallo-β-lactamase variants and different types of metallo-β-lactamases have attracted enormous consideration for hydrolyzing almost all β-lactam antibiotics, which leads to multi drug resistance bacteria. Metallo-β-lactamases genes have disseminated in hospitals and all parts of the world...
Molecular Diversity of NDM-1, NDM-5, NDM-6, and NDM-7 Variants of New Delhi Metallo-beta-Lactamases and Their Impact on Drug Resistance 来自 EBSCO 喜欢 0 阅读量: 41 作者: K Junaid 摘要: The emergence of multidrug-resistant bacteria has become a serious healthcare problem worldwide.#In ...