The drug is indicated as a monotherapy for chemo-pretreated patients or in combination with chemo for first-line treatment. In the first-line setting, Loqtorzi’s use on top of chemo cut the risk of death by 37% in the phase 3 JUPITER-02 trial. With about 2,000 new pati...
While interest in the drugs was originally focused on CLL, both have been shown to be efficacious in low-grade lymphomas. Ibrutinib is a highly selective inhibitor of Bruton tyrosine kinase (Btk),3 which is required not only for B-cell antigen receptor signaling, but is...
FDA Approves Lumakras (sotorasib) in Combination with Vectibix (panitumumab) for Chemorefractory KRAS G12C-Mutated Metastatic Colorectal Cancer Lumakras approval history Calquence (acalabrutinib) Capsules and Tablets New Indication Approved: January 16, 2025 Date of Original Approval: October 31, 2017...
Many drugs, or their antecedents, were discovered through observation of their effects on normal or disease physiology. For the past generation, this phenotypic drug discovery approach has been largely supplanted by the powerful but reductionist approach of modulating specific molecular targets of interest...
Invest. New Drugs 31, 707–713 (2013). CAS PubMed Google Scholar Brignone, C. et al. First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity. J. Transl. Med. 8, 71 (2010). PubMed Pub...
multiple myelomastem cell transplantationrelapseMultiple Myeloma (MM) is a common haematological malignancy, accounting for 10·0% of all bone marrow cancers in the UK (Velez etal, 2016). Chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard of care in transplant‐...
As standalone agents, they can clear tumor cells in a senescent state and, when combined with chemo- or radiotherapy, eliminate residual senescent cancer cells after treatment. This dual approach allows for the intentional use of lower-dose therapies or the removal of unintended senescent cells ...
Pembrolizumab (pembro) + chemotherapy (chemo) for advanced HER2-negative gastric or gastroesophageal junction (G/GEJ) cancer: Updated results from the KEYNOTE-859 study. S. Rha. Abstract #4045, Gastrointestinal Cancer—Gastroesophageal,...
metal complex that modulates zinc homeostasis to activate antitumor immunity, suggesting that zinc homeostasis-targeting drugs have significant potential in cancer chemotherapies and immunotherapies. In summary, zinc ions play various biological roles in cancer immunotherapy, including promoting the functions ...
In the past decade, the landscape of drugs approved for the treatment of multiple myeloma (MM) has rapidly grown, and several agents with novel mechanisms of action are currently in the pipeline.1 This, together with the availability of drugs with well-balanced efficacy/toxicity profiles has ...