Reports on the United States Food and Drug Administration's approval of the monoclonal antibody Herceptin for treating metastatic breast cancer. Mechanism of action; Role played by Herceptin in increasing the tumor-response rate and delaying the progression of the disease; Side effects....
New Drug Approved to Treat Metastatic Breast Cancer Tracy Hampton, PhD JAMA. 2015;313(12):1199. doi:10.1001/jama.2015.2195 Full Text The US Food and Drug Administration (FDA) has granted accelerated approval for the cyclin-dependent kinase (4/6) inhibitor palbociclib, or Ibrance, to be used...
The drug is also being tested in early breast cancer, according to Slamon, who added that China is included in its worldwide clinical trials. Pfizer is also collaborating with major university centers in Dalian, Liaoning province, Beijing and Shanghai in the research and developme...
"Metastatic triple-negative breast cancer is an aggressive form of breast cancer with limited treatment options," observed Richard Pazdur, MD, director of the FDA's Oncology Center of Excellence and acting director of the Office of Oncologic Diseases in the FDA's Center for Drug Evaluation and ...
New directions for drug-resistant breast cancer: the CDK4/6 inhibitors. Future Med Chem. 2015;7:1473-81... Mark,Nichols - 《Future Medicinal Chemistry》 被引量: 12发表: 2015年 Clinical Development of the CDK4/6 Inhibitors Ribociclib and Abemaciclib in Breast Cancer Clinical and preclinical ...
The study was also the first time the leukemia drug has been used on solid tumors; it was not currently approved in breast cancer and further studies would be required to determine its effectiveness, added Lindeman. "We are excited by the findings and what it could mean for patients with in...
Phase 1 asks the questions “Is an investigational drug or vaccine safe?” and “What is the correct dose?” Typically, these studies are done with a small group of healthy volunteers. But for some investigational therapies, such as those for cancer, the study is done with patients who have...
Cancer chemotherapy resistance: Mechanisms and recent breakthrough in targeted drug delivery 2023, European Journal of Pharmacology Citation Excerpt : These NPs provide the possibility of simultaneous diagnosis and treatment (Davodabadi et al., 2023). In addition, nanocarriers play a role in developing...
FDA Drug Approvals Q2 2024 Depiction of Cancer in Movies: Not an Accurate Portrayal Recommended Reading Sequencing Targeted Therapies in Metastatic HER2-Positive Breast Cancer Advanced and Metastatic Breast Cancer: A Shift in Thinking Fast Five Quiz: AKT in Advanced and Metastatic Breast Cancer...
Dec. 11, 2002 — Two presentations at the 25th Annual San Antonio Breast Cancer Symposium on Dec. 11 suggest new treatment options in advanced breast cancer refractory to conventional chemotherapy. A double-blind crossover trial showed that anastrozole (ARI) should be given as first-line adjuvant...