The monoamine hypothesis of depression has dominated treatment for decades, but for some with treatment‐resistant depression, alternative approaches are needed. This article discusses some of the other mechanisms involved in depression and how novel treatments could address these....
These new findings could help researchers better understand how mood states transition naturally. It also could lead to a more complete understanding of how fast-acting antidepressants (like ketamine) work and help researchers identify previously unknown targets for new antidepressant medications. The rese...
A dysfunctional response to stress, linked to a chronically overactive HPLA axis, causes anxiety disorders and depression; CRH-type 1 receptor antagonists like antalarmin are being investigated as potential anxiolytics and antidepressants. The deeper roots of our malaise lie buried in the evolutionary...
She completed her PhD programmet the University of British Columbia, studying neuroscience and behavioural neuroendocrinology, particularly investigating the effects of antidepressants on the maternal brain in an animal model of postpartum depression. She has a background in antibody and assay development....
the remaining 30% are partial or non-responders. Partial or non-responders to antidepressant medication tend to have poor quality of life, suicidal ideation, and long-term functional impairment. For this reason, there’s a major need to develop new antidepressants in 2018 to help the ~30% of...
The discovery of the strikingly rapid and robust antidepressant effects of r/s-ketamine for the treatment of antidepressant-resistant symptoms of depression has led to new insights into the biology of antidepressants and the FDA approval of its s-isomer, Esketamine (Spravato), the first ...
It remains the case that the majority of pharmacologic treatments for the major psychiatric disorders were initially discovered through serendipity and astute empiricism on the part of clinicians. Following the introduction of first-generation antipsychotics and antidepressants developed this way in the 1950...
Currently, classical antidepressants such as selective serotonin reuptake inhibitors (SSRIs), represented by sertraline, have side effects such as low drug resistance and many adverse effects [1]. People have questioned the potential addictive properties of newer antidepressants like ketamine, despite ...
To be eligible, psychedelic treatment (including MDMA, LSD, psilocybin, or ayahuasca) had to be given orally with no additional use of antidepressants, while escitalopram trials had to compare at least two different oral doses (maximum 20 mg/day) with placebo. Trials comparing psychedelic therapy...
precedent. Yet polypharmacy is scarcely anidealsolution for existing SSRI users. One of the major signs of depression is loss of interest in sex and reduced libido. So it's questionable whether the FDA and the pharmaceutical industry should continue to promote serotonergic "antidepressants" that are...