New antidepressants: monoamines and beyonddoi:10.1002/psb.2032Greener, MarkPrescriber
BMC Bioinformatics(2023) Editorial Summary New targets for old drugs Most drugs are intended to be selective for a single protein target, but will commonly bind to several other targets too. Some 'off-target' events induce side effects of varying degrees of severity, though some may be essentia...
Antidepressants for smoking cessation (Cochrane Review). Cochrane Database Syst. Rev. 4, CD000031 (2000). Google Scholar Holm, K. J. & Spencer, C. M. Bupropion: a review of its use in the management of smoking cessation. Drugs 59, 1007–1024 (2000). Article CAS PubMed Google ...
the remaining 30% are partial or non-responders. Partial or non-responders to antidepressant medication tend to have poor quality of life, suicidal ideation, and long-term functional impairment. For this reason, there’s a major need to develop new antidepressants in 2018...
Researchers at Northwestern University found that acute sleep deprivation enhances dopamine release and brain plasticity, causing a temporary uplifted mood and offering insights into potential new targets for antidepressants. A new study has found that acute sleep loss leads to an increase indopaminerele...
Dysphoria, irritability, anxiety, and sleep problems can respond to classic antidepressants and help patients manage symptoms and improve functioning. But the benefits of psychopharmacotherapy and psychotherapy are often small and incremental, and true remission is generally not obtained for months or ...
Pharmacological treatment of neuropathic pain consists mainly of the use of pregabalin, antidepressants, and opioids [2]. However, many patients do not respond to pharmacological treatment. For this reason, non-pharmacological approaches such as neuromodulation therapies have been developed [3]. Spinal ...
Antidepressants and type 2 diabetes: highways to knowns and unknowns Nahi Sabih Alruwaili Hayder M. Al-Kuraishy Gaber El-Saber Batiha Diabetology & Metabolic Syndrome (2023) Short-chain fatty acids: possible regulators of insulin secretion Nur Suraya Ashikin Rosli Shafinaz Abd Gani Mohd Bad...
It remains the case that the majority of pharmacologic treatments for the major psychiatric disorders were initially discovered through serendipity and astute empiricism on the part of clinicians. Following the introduction of first-generation antipsychotics and antidepressants developed this way in the 1950...
(SSRIs), tricyclic antidepressants (TCAs), bupropion, triptans, dietary supplements (eg, St. John's Wort, tryptophan), drugs that impair metabolism of serotonin (including monoamine oxidase inhibitors [MAOIs], which are contraindicated with FINTEPLA)...