“This work validates the benefits of machine learning in the search for new antibiotics. Using AI, we can rapidly explore vast regions of chemical space, significantly increasing the chances of discovering fundamentally new antibacterial molecules. We know broad-spectrum antibiotics are...
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infections. Drug X, as it is commonly known, targets certain proteins in a way that inhibits the DNA replication of bacteria that cause AMR. Drug X serves as the basis for what is expected to become the world’s first new class of antibiotics with new target proteins in nearly 40 years....
For this project, the researchers employed AI to identify ways to reengineer an existing antibiotic called Protegrin-1 that is great at killing bacteria, but toxic to people. Protegrin-1, which is naturally produced by pigs to combat infections, is part of a subtype of antibio...
Over the decades since the 1960s, the antibiotics research community has sought to broaden the number of clinically validated targets, using many rational as well as screening approaches. A particularly concerted effort went on with the advent of genome sequences of the most common bacterial ...
The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens1,2. These microorganisms have a highly restrictive permeability barrier, which limits the penetration of most compounds3,4. As a result, the last class of antibiotics that acted against Gram-negative...
Researchers from the University of Illinois at Chicago and Nosopharm, a biotechnology company based in Lyon, France, are part of an international team reporting on the discovery of a new class of antibiotics.
The AFM scanner was calibrated in the x, y and The Journal of Antibiotics MscL-targeting antibiotic I Iscla et al 461 z directions using silicon calibration grids (Bruker model numbers PG: 1 μm pitch, 110 nm depth and VGRP: 10 μm pitch, 180 nm depth). After acquiring the images, ...
59(9): 564–582, 2006 ORIGINAL ARTICLE L JTHE JOURNAL OF ANTIBIOTICS A New Series of Glycopeptide Antibiotics Incorporating a Squaric Acid Moiety Synthesis, Structural and Antibacterial Studies† Ferenc Sztaricskai, Gyula Batta, Pál Herczegh, Attila Balázs, József Jeko, Erzsébet Roth, Pál ...
However, the wide use of antibiotics not only causes metabolic burden (Corchero and Villaverde, 1998) but also raises safety concerns in livestock and food industries. Hence, antibiotic resistance genes are strictly limited in food and clinical areas, especially in gene therapy and DNA vaccination....