Miao X. Recent advances in the development of new transgenic animal technology. Cell Mol Life Sci 2013; 70: 815-828 [PMID: 22833168 DOI: 10.1007/s00018-012-1081-7]Miao, X. (2013) Recent Advances in the Development of New Transgenic Animal Technology. Cellular and Molecu- lar Life ...
Transgenic animal technology is one of the fastest growing biotechnology areas. It is used to integrate exogenous genes into the animal genome by genetic engineering technology so that these genes can be inherited and expressed by offspring. The transgenic efficiency and precise control of gene express...
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Advances in our understanding of the detrimental effects of inhaled irritants such as asbestos and silica have assisted in minimizing exposure to these NLRP3 activators. However, another potential threat to the lung comes from the increasing use of nanoparticles (eg, titanium dioxide) in diverse pro...
While the number of protein- encoding genes is relatively less variable among plants, the ncRNA domain in plants is very dynamic, with increasingly more ncRNA members being discovered and characterized annually. In particular, recent advances in NGS and ribosome profiling technology have offered great...
Recent advances in single-cell sequencing have undermined the possibility of applying the M1/M2 system to microglia; microglia cannot be described well using this system [91]. Recently, a comprehensive single-cell RNA analysis technique discovered disease-related microglia (DAM), a subpopulation of ...
single target and high immunotoxicity limit its clinical application. The multiple immunomodulatory potential of traditional Chinese medicine (TCM) provides a new direction for improving the treatment of T cell exhaustion. Here, we review recent advances that have provided a clearer molecular understanding...
New therapies are developed based on a detailed understanding of the mechanisms of autoimmune diseases.4In this review, we describe the epidemiology, clinical diagnosis, pathogenesis, mechanisms and therapies of autoimmune diseases. We provide a timeline to summarize the significant advances in the field...
These studies looked at the effects of laser therapy in combination with other therapies like pharmacotherapies, physical therapies, exercises, stem cells, and experimental materials on neurological disorders in both animal models and humans. The findings suggested that most combination therapies could ...
In recent years, we have risen to unprecedented technological advances in the single-cell RNA-sequencing (scRNA-seq) field allowing to study the transcriptional information enclosed in cells. In 2017, this stimulated the formation of the Human Cell Atlas [2], an international collaborative effort ...