In alpha 1-antitrypsin deficiency, for example, inflammation, part of a normal immune response, leads to tissue damage. In Familial Mediterranean fever, the immune response is also so acute and prolonged that it can lead to a number of dangerous complications. Share The Health Board is ...
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As a facultative anaerobe, Sal exhibits a preference for colonizing tumor sites, but its non-specific distribution in normal tissue organs may cause side effects. Using a mouse 4T1 breast cancer xenograft model, we studied the in vivo distribution of the Sal after tail vein administration. We e...
www.nature.com/scientificreports OPEN received: 28 January 2016 accepted: 20 May 2016 Published: 22 June 2016 Attenuated viral hepatitis in Trem1−/− mice is associated with reduced inflammatory activity of neutrophils Jan-Hendrik Kozik1, Tanja Trautmann1, Antonella Carambia1, Max ...
altered transcripts per cell or both. This analysis showed that the cell count did not account for the observed difference in gene-expression since leukocytes in both groups were within normal ranges: moderate (8.1 × 1000/mm3) and severe (9.6 × 1000/mm3). Furthermore, leukocyte...
Furthermore, the average NLR value increased with tumor progression (Fig. 6a–c). The patients were subsequently divided into two groups based on the median pre-operative NLR value (1.93, range: 0–18.4). Patients with a high NLR had a significantly higher average number of CD15+TANs in ...
and parameter value) instead of a single possibility (e.g., parameter value). If the decision rules fail to account for all variables, potentially erroneous results might not be flagged for review, e.g., if a total neutrophil count appears to be normal, but only because EGCs were excluded...
In addition, however, we discovered three adnormal populations of mature PMN: (1) PMN containing both populations of granules but lacking peroxidase, (2) PMN lacking specific granules, and (3) PMN lacking azurophil granules. Our findings emphasize the value of electron microscopy and cytochemistry...
Clonality values range from 0 to 1, with a value of 1 representing a monoclonal population. TCR-β sequences only present in tumour but not in non-adjacent lung tissue (identified using log10scatter plots) were defined as TAC. Generation of tumour-infiltrating lymphocyte (TIL) populations ...
The center line represents the sample median, the box limits consist of the 25th and 75th percentiles, the whiskers span 1.5x the interquartile range, and each RNA-seq sample is represented by a point on the graph. All uncropped western blot images and quantification data is been made ...