In conclusion, earlier sections clearly indicate that neutrophils are a ‘double-edged sword’ type of immune system that makes the neutrophil compartment complex. Traditionally, immune-mediated diseases are treated with inhibitors (‘antagonists’), as the use of activators (‘agonists’) is thought ...
In conclusion, earlier sections clearly indicate that neutrophils are a ‘double-edged sword’ type of immune system that makes the neutrophil compartment complex. Traditionally, immune-mediated diseases are treated with inhibitors (‘antagonists’), as the use of activators (‘agonists’) is thought...
O. et al. Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma. Cancer 118, 2476–2485 (2012). Article CAS PubMed Google Scholar Carus, A. et al. Tumor-associated neutrophils and macrophages in ...
These data together indicate that cytoskeleton remodelling as a result of calpain activity regulates NETosis and improves cell motility. In conclusion, we demonstrat that Ca2+ influx via Piezo1 regulates NETosis in neutrophils subjected to shear stress. Furthermore, we conclude that shear stress-...
What are Neutrophils? white blood cell, comprising about 50-70% of all white blood cells. They are phagocytic, meaning that they can ingest other cells, though they do not survive the act. Neutrophils are the first immune cells to arrive at a site of infection, through a process known as...
What is the normal range for segmented neutrophils? What are normal neutrophil levels? Why are hypersegmented neutrophils involved in megaloblastic anemia? What does a high eosinophil count indicate? What are immature neutrophils? What are absolute neutrophils? How can neutrophils be decreased? What ca...
Our preliminary observations (H.L.M. et al., unpublished data) indicate the following: (1) it may be a proportion of the trogocytic events that leads to definitive target cell lysis, and (2) there clearly appears to be an effect of accumulation of the trogocytosis-related membrane damage...
Our knowledge of the pathophysiology about traumatic brain injury (TBI) is still limited. Neutrophils, as the most abundant leukocytes in circulation and the first-line transmigrated immune cells at the sites of injury, are highly involved in the initiat
Future studies targeting neutrophils in chronic inflammation need to consider methods to limit the side effects of treatments. Neutrophils are critical in the acute inflammatory response to infection, and the complete ablation of neutrophils will lead to increased risks of infection, as with the antagon...
1d). These results indicate that neutrophils are sensitive to shear stress and that increased shear stress can directly induce NETosis. Next, we investigated the effect of shear stress on the sensitivity of neutrophils to other NET-inducing agents such as ATP, LPS, and PMA. For this assessment...