HIGH NEUTROPHILS/LYMPHOCYTE RATIO AND MPO LEVELS ASSOCIATED WITH LOW EXPRESSION OF MIRNA-146A AND APOLIPOPROTEIN E IN TYPE2 DIABETIC PATIENTS WITH ATHEROSCLEROSISTHAABAN ALMZAIEL, ANWAR JASIBJABBAR, NAWAL KHINTEELAL-ABADY, ZAINB NAJAMSABIT, REMAH ABDULHASSAN...
通过蛋白质构象的改变,促使内皮细胞上的ICAM1和中性粒细胞上的macrophage-1antigen ,MAC1相互作用。 这会导致中性粒细胞向趋化因子浓度高(high concentrations of chemoattractants)的地方移动。 也就是说,炎症部位释放趋化因子,中性粒细胞感知到它们,从而通过“爬行”慢慢朝炎症方向移动,这也可以理解为“趋化”的作用。
In transcellular migration, transmigratory cups high in ICAM-1 and VCAM-1 capture crawling neutrophils that then make their way through the cells. Once out in tissues, a burst of transcriptional activity in part mediated by local G-CSF production initiates generation of cytokines by neutrophils. ...
HIGH-AFFINITY RECEPTORPOLYMORPHONUCLEAR LEUKOCYTESRHEUMATOID-ARTHRITISDEPENDENT INDUCTIONALLERGEN EXPOSUREHistamine is an important mediator in the development of allergic reactions. Only a small subset of human cell types is able to produce histamine. No previous studies have shown that human neutrophils are...
(Fig.4b). However, examination of the expression of the core inflammation program on a single cell level indicated heterogeneity within the population of neutrophils, which was characterized by the presence of groups of cells with exceptionally high or low expression of the defined gene set in ...
A. et al. Prognostic value of intratumoral neutrophils in advanced gastric carcinoma in a high-risk area in northern Italy. Mod. Pathol. 15, 831–837 (2002). Article PubMed Google Scholar Jensen, H. K. et al. Presence of intratumoral neutrophils is an independent prognostic factor in ...
Acute inflammation triggers the innate immune response of neutrophils that efficiently traffic from the bloodstream to concentrate at high numbers at the site of tissue infection or wounding. A gatekeeper in this process is activation of β(2) integrins, which form bond clusters with ICAM-1 on th...
IL-4 Expression by Neutrophils in Psoriasis Lesional Skin upon High-Dose UVB Exposure Background: Upon a single high dose of UVB irradiation of psoriatic lesional skin, IFN-γ expression is decreased, whereas IL-4 expression is enhanced... G Piskin,U Tursen,JD Bos,... - 《Dermatology》 被...
The neutrophils have been easy to overlook, as they are present in the lung at all times, even in non﹕ymptomatic asthmatic patients.doi:10.1111/cea.13602Sandra EkstedtOlivia LarssonSusanna Kumlien GeorénLars Olaf CardellClinical & Experimental Allergy...
In the context of cardiovascular complications of atherosclerosis, we highlight the dichotomous role of neutrophils in pathogenic and repair processes in stroke, heart failure, myocardial infarction and neointima formation. Finally, we emphasize how detailed knowledge of neutrophil functions in cardiovascular...