These studies highlight the confused neutrophil response in tumor immunology, which involves its normal armamentarium toward tumor and host cells rather than toward microorganisms (Table 1). Therefore, it is important to describe these adequate mechanisms first in health followed by a description of ...
46It is thought that these neutrophils are retained in the lung actively by upregulation of the chemokine receptor CXCR4, which binds CXCL12, a ligand expressed by a subset of lung endothelial cells.47The role of these resident lung
Neutrophils are normally isolated via density centrifugation because neutrophils (and eosinophils) have a higher buoyant density than mononuclear cells do. It seems that a shift to a lower buoyant density of hypodense neutrophils occurs via the activation of neutrophils in vitro and in vivo and does...
In transcellular migration, transmigratory cups high in ICAM-1 and VCAM-1 capture crawling neutrophils that then make their way through the cells. Once out in tissues, a burst of transcriptional activity in part mediated by local G-CSF production initiates generation of cytokines by neutrophils. ...
In 2015, it was estimated that 1 in 11 adults globally (approximately 415 million people) aged 20–79 years, had diabetes, and over 90% of diabetes mellitus cases were T2DM. T2DM is a chronic disease characterized by high levels of glucose in the blood, impaired insulin secretion and/or ...
Similar to some viruses (described in Section 4.1), tumor cells may express high levels of phosphatidylserines or related phospholipids as well, which as a result, may inhibit NK cell-mediated killing through CD300a [222]. This has not been investigated for neutrophils. Another example is colla...
The receptors expressed on neutrophils may function, at least in part, in a high-order complex involving homo- or heterodimerization that leads to distinct signalling outcomes [39]. Chemokine receptor trafficking to the cell membrane is likely to occur as oligomers [40]. The dimerization status ...
Traumatic brain injury (TBI) is a complex injury that causes the marked brain pathology, disruption of the normal function of the brain, and death. It is an important public health issue considering not only its high mortality rate but also the numerous complications in the patients who survive...
In 2015, it was estimated that 1 in 11 adults globally (approximately 415 million people) aged 20–79 years, had diabetes, and over 90% of diabetes mellitus cases were T2DM. T2DM is a chronic disease characterized by high levels of glucose in the blood, impaired insulin secretion and/or ...
High mobility group 1 B-box mediates activation of human endothelium J Intern Med, 254 (4) (2003), pp. 375-385 View in ScopusGoogle Scholar 96 GM Thomas, A Brill, S Mezouar, et al. Tissue factor expressed by circulating cancer cell-derived microparticles drastically increases the incidence...