The low absolute cell count and the apparent neutrophil dysfunction both predispose the individual to bacterial infection. 3.3.3.2 Rheumatoid arthritis Neutropenia in RA patients is due to both being related to severe disease and immunosuppression, and can be associated with Felty's syndrome or with ...
(2010) Automated Determination of Neutrophil Volume as Screening Test for Late-Onset Sepsis in Very Low Birth Infants. Pediatr Infect Dis J 29(3): 288.Raimondi F, Ferrara T, Capasso L, Sellitto M, Landolfo F, Romano A et al. Auto- mated determination of neutrophil volume as screening ...
Many groups have sought to identify the surface molecules implicated in IgG-mediated leukocyte dysfunction. Due to the wealth of potential autoantigens associated with both SLE and RA, identification of a singular antigen target has been met with varying degrees of success and is likely to be com...
cDNA libraries were prepared from RNA samples using the Clontech SMARTer universal low input RNA kit to maximize yield, and samples were sequenced on Illumina NovaSeq S4 XP (paired 150 bp reads). After adapter trimming using Trimmomatic v0.3977, sequenced RNA-seq reads were aligned to theMacaca...
The relative levels of the target proteins were determined using a ChemiDocTM MP system operated by Image LabTM software (Bio-Rad) in an auto-exposure mode, and they were normalized either by β-actin or β-tubulin. The amounts of the proteins used for electrophoresis were as follows: ...
Both box plots show enriched cell types in percent of total hits; absolute hits with respect to cluster size are stated aside. c Gene set variation analysis was conducted for every single patient based on Hallmark gene sets as shown in Fig. 2d. The result was standardized to retrieve the z...
Despite effective therapeutic and preventive strategies, atherosclerosis and its complications still represent a substantial health burden. Leukocytes and inflammatory mechanisms are increasingly recognized as drivers of atherosclerosis. Neutrophil granulocytes within the circulation were recently shown to undergo n...
Shown is the percentage (left panel) and the absolute cell number (right panel) of neutrophils in the CD45+CD11b+ population. Neutrophils of wild-type mice were identified by their Ly6G expression; those of Ly6G-deficient mice were detected by their expression of tdTomato. Non-significant ...
c The proliferation of Cilta-cel in the peripheral blood (n = 12) shown by the absolute number (mean ± SEM). d The chart shows the CD8:CD4 ratio of CAR-T (n = 9). Data is presented as mean ± SEM. e The chart presents the immnunophenotypic signature of CAR-...
and that mne macrophages can reconstitute after ablation indicate that intact Zbtb11 is dispensable for primitive macrophage development but becomes rate-limiting as reliance on HSC self-renewal and differentiation increases and becomes absolute following the onset of definitive haemopoiesis. The ...