Chronic idiopathic neutropenia of adults was identified in 34.0% of the individuals, neutropenia due to exposure to chemical agents was seen in 16.5%, infectious diseases in 9.3%, autoimmune diseases in 9.3%, haematological diseases in 9.3%, thyroid disorders in 8.2%, ethnic neutropenia in 7.2%,...
A person with a neutrophil count of 1500 neutrophils per microliter or less is considered a neutropenic in adults. In children these numbers change. If the levels fall below 500 then it is considered to be severe neutropenia. In such cases even the natural bacteria present in the stomach, ski...
Table 1. Causes of neutropenia in adults Congenital* Constitutional neutropenia Ethnic neutropenia Benign familial neutropenia Cyclic neutropenia Acquired Infection-associated Post-infectious Active infection (sepsis, viruses) Drug-induced Agranulocytosis Mild neutropenia Autoimmune Primary autoimmune Secondary autoi...
Autoimmune neutropenia.This is the most common cause of neutropenia in infants and young children. Occasionally, it is seen in adults aged 20-40 years (mostly women). The condition causes the body's immune system to fight and destroy its own neutrophils. Febrile neutropenia.While not one of t...
Often, neutropenia in adults is due to acquired causes such as drug induced or arises post infection. Felty’s syndrome is a well-characterized clinical abnormality consisting of rheumatoid arthritis, splenomegaly, and severe neutropenia. The cause could be attributed to increased neutrophil margination...
To analyze the prevalence of neutropenia in a large cohort of patients with primary Sj枚gren's syndrome (SS) and its association with clinical and immunolo... P Brito-Zerón,N Soria,S Muoz,... - 《Semin Arthritis Rheum》 被引量: 61发表: 2009年 Autoimmune neutropenia in adults Autoimmune...
In 2002, the first long-acting G-CSF, pegfilgrastim, was approved in Europe for reducing the duration of neutropenia and the incidence of febrile neutropenia in adults receiving cytotoxic chemotherapy for cancer [76]. Pegfilgrastim may be preferred over filgrastim by patients and physicians owing to...
Neutropenia is a common laboratory finding in adults and children. Its underlying causes are extremely heterogeneous and include benign conditions, autoimmune disorders, infections, and malignancies. The clinical laboratory plays a central role in the diagnosis of these disorders, including data derived fr...
Table 1. Causes of autoimmune neutropenia in adults. Primary autoimmune neutropenia Secondary autoimmune neutropenia Alternating autoimmune hemocytopenia Autoimmune diseases Systemic lupus erythematosus Rheumatoid arthritis (Felty's syndrome) Sjögren's syndrome Scleroderma Primary biliary cirrhosis Graves' disease...
In addition, some clinical syndromes of immune neutropenia have been better defined over the past decade, such as autoimmune neutropenia of infancy and chronic idiopathic neutropenia in adults. The past decade also saw interesting developments in the treatment of immune neutropenia, particularly in the...