Excessive alcohol use is the cause of an ongoing public health crisis, and accounts for ~5% of global disease burden. A minority of people with recreational alcohol use develop alcohol addiction (hereafter equated with "alcohol dependence" or simply "alcoholism"), a condition characterized by a ...
Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and co...
addictionbehavioranimal modelsgeneticspreclinical medications developmentMounting evidence over the last 40 years clearly indicates that alcoholism (alcohol dependence) is a disorder of the brain. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has taken significant steps to advance research...
Physical dependence refers to the adaptations that result in withdrawal symptoms when drugs such as alcohol and heroin are discontinued. Those are distinct from the adaptations that result in addiction, which refers to the loss of control over the intense urges to take the drug even at the expens...
neurotrophic factor, activity-regulated cytoskeleton-associated protein, and corticotrophin-releasing factor, that may play a crucial role in the behavioral effects of ethanol and molecular changes in the specific neurocircuitry that underlie both alcohol addiction and a genetic predisposition to alcoholism...
Behavioral perspectives on the neuroscience of drug addiction. G Winger,JH Woods,CM Galuska,... - Society for the Experimental Analysis of Behavior 被引量: 0发表: 2005年 Alcohol Craving and Relapse Prediction: Imaging Studies -- Advances in the Neuroscience of Addiction After detoxification, ...
It has become increasingly clear that molecular and neural mechanisms underlying learning and memory and drug addiction are largely shared. To confirm and extend these findings, we analyzed ethanol-responsive behaviors of a collection of Drosophila long-term memory mutants. For each mutant, sensitivity...
Addiction to nicotine, alcohol, opioids, and other drugs is one of the leading public health and safety challenges of our time.1 In the United States, more than 25 million people smoke cigarettes, and more than 20 million people meet diagnostic criteria for other substance use disorders, which...
Rehabilitation from alcohol addiction or abuse is hampered by withdrawal symptoms including severe headaches, which often lead to rehabilitation failure. There is no appropriate therapeutic option available for alcohol-withdrawal-induced headaches. Here, we show the role of the mast-cell-specific receptor...
Alcohol Putative Psychoactive Effects (GABRA2). In human association studies, variation in gamma amino butyric acid receptor A (GABAA) genes, particularly the gene encoding the alpha 2 subunit (GABRA2), have been routinely implicated in the etiology of alcohol addiction [14–18]; however see [...